Ves-ATRA 10 mg Capsules

Ves-ATRA 10 mg Capsules contain 10 mg of tretinoin in each capsule. Tretinoin is an anti-cancer medicine called a retinoid, and this oral capsule is used in the treatment of acute promyelocytic leukemia (APL), a specific type of blood cancer. Ves-ATRA 10 mg Capsules are a prescription-only medicine and should be used only under a doctor’s supervision.

How it works: Tretinoin helps immature leukemia cells in APL mature into normal-appearing cells, which can reduce the buildup of abnormal promyelocytes in the blood and bone marrow. Because Ves-ATRA 10 mg Capsules is taken by mouth, the medicine is absorbed through the digestive tract and works throughout the body.

Ves-ATRA 10 mg Capsules is a relatively high-strength tretinoin capsule, so it is not meant for self-starting or routine use without specialist assessment. Doctors choose this strength when an adult patient needs a full systemic dose for APL treatment and when capsule-based dosing is appropriate for the treatment plan.

• Treatment of acute promyelocytic leukemia (APL)
• Part of a specialist cancer treatment plan
• Induction therapy in newly diagnosed APL
• Maintenance or consolidation only when prescribed by an oncologist

• Take Ves-ATRA 10 mg Capsules exactly as prescribed by your oncology team.
• Swallow the capsule whole with water; do not open, crush, or chew it.
• Take it with food as directed, because taking it with a meal may help absorption.
• Follow the same dosing schedule each day if your doctor prescribes regular daily use.
• Do not change the dose on your own, even if you feel better or have side effects.
• If you miss a dose, contact your doctor or pharmacist for instructions rather than doubling up.

Each Ves-ATRA 10 mg Capsule provides 10 mg of tretinoin. For APL, the total daily dose is usually calculated by body surface area and may be given in divided doses; the exact frequency and maximum daily amount are set by the doctor based on the treatment protocol, weight, response, and lab results. This is a higher-strength cancer medicine, so dosing must be individualized and closely monitored.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Tretinoin may include:

• Headache
• Dry skin and dry lips
• Mouth sores
• Nausea or vomiting
• Bone or joint pain
• Fever or fatigue
• Raised liver tests or changes in blood counts

• Do not use during pregnancy unless your cancer specialist specifically directs it; tretinoin can cause severe birth defects.
• Use effective contraception as instructed before, during, and after treatment.
• This 10 mg strength is for cancer treatment only and should not be used for acne or other skin problems.
• Avoid vitamin A supplements unless your doctor approves, because they can increase retinoid-related toxicity.
• Tell your doctor if you have liver disease, high cholesterol, or a history of blood clots.
• Use caution when driving or operating machinery if you have headache, dizziness, or vision changes.
• Avoid alcohol or ask your doctor first, because it may worsen liver-related side effects.

• Tetracycline antibiotics may increase the risk of increased pressure in the brain.
• Vitamin A supplements or other retinoids can raise toxicity.
• Certain antifungal or antibiotic medicines may affect tretinoin levels or side effects.
• Blood thinners or medicines that affect clotting may increase bleeding risk during treatment.
• Live vaccines should be discussed with the oncology team before use.

Store Ves-ATRA 10 mg Capsules at room temperature in the original strip/box, protected from heat, moisture, and light, and keep it out of reach of children.