Lethyrox 125 Tablet

Lethyrox 125 Tablet is a levothyroxine (thyroxine) tablet that contains 125 mcg of levothyroxine sodium in each tablet. It belongs to the thyroid hormone replacement class and is used to treat hypothyroidism, a condition where the thyroid gland does not make enough hormone. It may also be prescribed for certain other thyroid-related uses when a clinician determines thyroid hormone replacement is needed. Because Lethyrox 125 Tablet is a higher-strength tablet, it is usually selected for patients whose dose has already been carefully assessed and adjusted by a doctor.

How it works: Levothyroxine is a synthetic form of the natural thyroid hormone T4. After you swallow Lethyrox 125 Tablet, your body converts it to the active hormone T3, which helps regulate energy use, temperature, heart rate, and metabolism.

Compared with lower strengths such as Lethyrox 12.5 Tablet, 50 Tablet, 75 Tablet, 88 Tablet, and 100 Tablet, Lethyrox 125 Tablet delivers a larger hormone amount in one tablet. This makes it useful when a patient needs an intermediate-to-higher maintenance dose and a doctor wants fewer tablets to reach the prescribed amount. Levothyroxine dosing is individualized, so this strength is not a starting dose for most people and is chosen based on labs, symptoms, age, weight, and heart risk.

• Hypothyroidism
• Thyroid hormone replacement
• Support after thyroid removal or thyroid ablation
• Treatment of certain goiter-related thyroid conditions as prescribed

• Take Lethyrox 125 Tablet exactly as prescribed, usually once daily.
• Swallow the tablet whole with a full glass of water; do not crush or chew unless your prescriber specifically tells you to.
• Take it on an empty stomach, ideally 30 to 60 minutes before breakfast, for best and most consistent absorption.
• Keep it separate from calcium, iron, antacids, or multivitamins by at least 4 hours unless your doctor says otherwise.
• Take it at the same time every day to keep thyroid levels steady.
• If you miss a dose, take it when you remember the same day; do not double up unless your clinician instructs you to.

Each Lethyrox 125 Tablet contains 125 mcg of levothyroxine. It is usually taken once daily, but the exact schedule and total daily dose are determined by the doctor based on thyroid tests and your response; in some patients, the prescribed daily amount may be adjusted using lower-strength tablets or combinations of strengths. Do not increase the dose on your own, because too much thyroid hormone can be harmful.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Thyroxine / Levothyroxine may include:

• Nervousness or feeling shaky
• Headache
• Trouble sleeping
• Increased sweating
• Fast heartbeat or palpitations
• Diarrhea
• Weight loss or decreased appetite, especially if the dose is too high

• Lethyrox 125 Tablet is a higher strength, so dosing mistakes can cause symptoms of overactive thyroid if taken in excess.
• Tell your doctor if you have heart disease, arrhythmia, angina, high blood pressure, or a history of heart attack.
• Use extra caution if you are pregnant or breastfeeding, because thyroid hormone needs can change and monitoring is important.
• Do not take it at the same time as calcium, iron, antacids, bile acid sequestrants, or fiber supplements unless directed.
• Let your clinician know about diabetes or adrenal problems, since thyroid replacement can affect those conditions.
• If you have osteoporosis or are at risk for bone loss, your dose should be monitored carefully.
• Driving is usually not affected, but if you feel dizzy, shaky, or have palpitations, avoid driving until you feel well.

• Calcium supplements and calcium-containing antacids
• Iron supplements and multivitamins with iron
• Cholestyramine, colesevelam, or colestipol
• Warfarin
• Certain seizure medicines such as phenytoin or carbamazepine

Store Lethyrox 125 Tablet in its original strip/box at room temperature, away from moisture, heat, and direct light.