Sitahenz M 500 Tablet PR

Sitahenz M 500 Tablet PR is a prescription diabetes medicine that combines sitagliptin and metformin in each tablet, with the metformin part labeled as 500 mg in a prolonged-release (PR) tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes. Sitahenz M 500 Tablet PR is not for type 1 diabetes or diabetic ketoacidosis. The PR tablet is designed to release medicine more gradually than immediate-release tablets.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar the liver makes. Metformin helps reduce sugar production in the liver and improves how the body responds to insulin, and the tablet’s prolonged-release form delivers metformin more steadily through the day.

Sitahenz M 500 Tablet PR is the lower metformin-strength option in this product and is often chosen when a doctor wants a gentler starting or maintenance tablet that may be easier on the stomach than higher metformin doses. Because it is a prolonged-release tablet, it is meant to be swallowed whole and may feel different from immediate-release tablets in how it releases medicine over time. This strength can fit patients who need combination treatment but do not yet need a higher metformin dose.

• Type 2 diabetes mellitus
• Blood sugar control with diet and exercise
• Combination treatment when one medicine is not enough
• May help lower fasting and after-meal glucose

• Swallow Sitahenz M 500 Tablet PR whole with water; do not crush, chew, or split it.
• Take it with food, usually with the evening meal if your prescriber directs once-daily use, to help reduce stomach upset.
• If your prescription says to take it more than once daily, take it exactly at the times prescribed.
• Do not change to a different metformin or sitagliptin product unless your clinician tells you to.
• If you miss a dose, take it when remembered unless it is almost time for the next dose; do not double up.

Each Sitahenz M 500 Tablet PR contains sitagliptin plus metformin 500 mg in a prolonged-release tablet. The exact dosing schedule is individualized by the doctor; in general, this kind of tablet is taken once daily, but some patients may be instructed to take it differently depending on prior diabetes medicines and kidney function. Do not exceed the maximum daily amount prescribed by your clinician, since both the dose and frequency must be adjusted for safety.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset or abdominal pain
• Gas or bloating
• Headache
• Upper respiratory symptoms such as runny nose or sore throat

• Tell your doctor if you have kidney disease, because metformin-containing products may need dose changes or may not be appropriate.
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis with metformin.
• Use caution if you have a history of pancreatitis, heart failure, or severe dehydration.
• This tablet may cause low blood sugar when combined with insulin or other diabetes medicines that can lower glucose.
• Do not use it for type 1 diabetes or diabetic ketoacidosis.
• Be careful when driving or operating machinery if you notice dizziness or low blood sugar symptoms.
• If you are having surgery, severe infection, vomiting, or not eating normally, contact your clinician for advice about temporary holding of diabetes medicines.

• Insulin and sulfonylureas may increase the risk of hypoglycemia.
• Alcohol can increase the risk of metformin-related lactic acidosis.
• Iodinated contrast dyes used for some imaging tests may require temporary stopping of metformin-containing medicines.
• Strong enzyme or transporter-interacting medicines may affect sitagliptin levels or kidney handling of metformin, so all prescription and OTC medicines should be reviewed.
• Other glucose-lowering medicines may require dose adjustments to avoid low blood sugar.

Store Sitahenz M 500 Tablet PR in its original strip/box at room temperature, away from moisture and excessive heat, and keep it out of reach of children.