Mesacol 500 mg Suppository

Mesacol 500 mg Suppository is a rectal mesalazine (mesalamine) medicine used for inflammatory bowel disease. Each suppository contains 500 mg of mesalazine, an aminosalicylate drug that acts directly in the bowel. It is commonly used to treat ulcerative proctitis and inflammation in the lower part of the rectum. By delivering medicine right where the inflammation is, Mesacol 500 mg Suppository can help reduce urgency, bleeding, and rectal discomfort.

How it works: Mesalazine works by calming inflammation in the lining of the bowel, which can reduce swelling and irritation. As a suppository, Mesacol 500 mg delivers the medicine directly to the rectum so it can work locally where symptoms start.

Mesacol 500 mg Suppository is a lower-strength rectal option that may be chosen when a doctor wants targeted treatment for mild to moderate inflammation in the rectum. Because it is a suppository rather than an oral tablet, it acts locally in the lower bowel instead of being swallowed and absorbed through the stomach. This form is useful when inflammation is limited to the rectal area and a clinician wants a medicine that stays in place overnight or during rest.

• Ulcerative proctitis
• Mild to moderate ulcerative colitis affecting the rectum
• Reducing rectal bleeding
• Helping with rectal urgency and mucus
• Maintaining remission when prescribed by a doctor

• Use exactly as prescribed by your doctor; this is a rectal suppository, not a tablet to swallow.
• Wash your hands before and after inserting the suppository.
• Remove the suppository from the wrapper and insert it into the rectum as directed, usually after a bowel movement and preferably at bedtime.
• Do not cut, crush, or swallow the suppository.
• Try to stay lying down for a short time after insertion so the suppository can stay in place.
• Follow the prescribed schedule even if symptoms improve; stopping early can let symptoms return.

Each Mesacol 500 mg Suppository contains 500 mg of mesalazine. The exact number of suppositories per day depends on the condition being treated and the doctor’s plan; rectal mesalazine is often used once daily, but some patients may be told to use it more than once daily. Do not use more than the prescribed amount per day, because your doctor should decide the right dose for your symptoms and response.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Mesalazine / Mesalamine may include:

• Rectal irritation or discomfort
• Anal pain or burning
• Gas or bloating
• Abdominal pain
• Headache
• Nausea
• Loose stools or diarrhea

• Do not use Mesacol 500 mg Suppository if you are allergic to mesalazine, aspirin, or other salicylates unless your doctor says it is safe.
• Tell your doctor if you have kidney disease, because mesalazine can affect kidney function and may need monitoring.
• Use caution if you have liver disease or a history of pancreatitis.
• Report worsening rectal bleeding, fever, or severe abdominal pain promptly, as these may not be normal treatment effects.
• Tell your clinician if you are pregnant, planning pregnancy, or breastfeeding, so the benefit and risk can be reviewed.
• Let your doctor know about any blood disorders or a history of heart inflammation, which can rarely occur with mesalazine.
• Do not use other mesalazine or sulfasalazine products at the same time unless your doctor has specifically instructed you to do so.

• Other nephrotoxic medicines, including NSAIDs such as ibuprofen or naproxen, may increase kidney risk.
• Azathioprine or 6-mercaptopurine may increase the risk of blood-related side effects.
• Warfarin and other blood thinners may require closer monitoring.
• Aspirin or other salicylates can increase the chance of side effects or allergy problems.

Store Mesacol 500 mg Suppository in a cool, dry place away from heat and moisture, and keep it in the original packaging until use.