Duonase Nasal Spray 140 mcg + 50 mcg

Duonase Nasal Spray 140 mcg + 50 mcg is a prescription nasal spray that combines fluticasone propionate, a corticosteroid, and azelastine, an antihistamine, in one bottle. Each spray delivers 140 mcg of fluticasone propionate plus azelastine to help relieve allergy symptoms in the nose. It is used for allergic rhinitis, including sneezing, runny nose, nasal congestion, and itchy nose. This product is meant for people who need a doctor-assessed dual-action nasal spray rather than a basic single-ingredient allergy spray.

How it works: Fluticasone propionate reduces inflammation inside the nose, which helps calm swelling and congestion caused by allergies. Azelastine blocks histamine, the chemical that triggers sneezing, itching, and a runny nose, and the spray form lets both medicines work directly where symptoms start.

Duonase Nasal Spray 140 mcg + 50 mcg is a higher-strength option that is chosen when a clinician wants stronger combined treatment for persistent or more bothersome nasal allergy symptoms. Because it contains both a steroid and an antihistamine in one spray, it may feel more effective for congestion plus sneezing and itching than either ingredient alone, but it should be used only as directed for this specific strength.

• seasonal allergic rhinitis
• perennial allergic rhinitis
• sneezing
• runny nose
• itchy nose
• nasal congestion

• Use Duonase Nasal Spray 140 mcg + 50 mcg exactly as your doctor prescribes; do not take extra sprays because this is a higher-strength product.
• Prime the spray before first use if your pharmacy instructions or package leaflet say to do so.
• Blow your nose gently before using the spray so the medicine can reach the nasal lining.
• Keep your head slightly tilted forward, insert the nozzle into one nostril, and spray while breathing in gently through the nose.
• Avoid spraying directly toward the nasal septum, and switch nostrils as directed.
• Wipe the nozzle after use and replace the cap to keep the spray clean.

Each spray of Duonase Nasal Spray 140 mcg + 50 mcg delivers 140 mcg of fluticasone propionate along with azelastine in the same spray. The exact number of sprays per day varies by patient and condition; your doctor decides how often to use it and the maximum daily dose based on your symptoms and response. Do not use more than prescribed, especially with this stronger combination nasal spray.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Fluticasone Propionate + Azelastine may include:

• bitter taste after spraying
• nosebleed
• nasal irritation or burning
• sneezing right after use
• headache
• dry nose
• mild drowsiness or tiredness

• Use only in the nose; do not swallow or inject Duonase Nasal Spray 140 mcg + 50 mcg.
• This is a higher-strength prescription spray, so follow the exact dose your doctor gives and do not self-increase if symptoms are not controlled.
• Tell your doctor if you have frequent nosebleeds, recent nasal surgery, nasal ulcers, or an injured nose.
• Use caution if you feel sleepy or dizzy after the azelastine component; avoid driving until you know how Duonase Nasal Spray 140 mcg + 50 mcg affects you.
• Tell your doctor about glaucoma, cataracts, liver disease, or any history of steroid-related problems.
• If you are taking other allergy medicines, do not combine them unless your clinician says it is okay.
• Long-term or excessive use of nasal corticosteroids may increase the risk of nose and throat effects, so follow up if symptoms persist.

• other antihistamines such as diphenhydramine, cetirizine, or loratadine unless approved by your doctor
• other nasal sprays or inhalers containing corticosteroids
• sedatives, sleeping pills, or alcohol because drowsiness may be stronger
• certain HIV medicines or strong CYP3A4 inhibitors that can raise steroid exposure
• other medicines that cause dry mouth, dizziness, or sleepiness

Store Duonase Nasal Spray 140 mcg + 50 mcg at room temperature, upright if possible, and keep the cap on when not in use.