Atranza 10 mg Capsules

Atranza 10 mg Capsules is a prescription anti-cancer medicine that contains tretinoin 10 mg in each capsule. Tretinoin is a retinoid, a vitamin A–related drug used in acute promyelocytic leukemia (APL), usually as part of a specialist treatment plan. Atranza 10 mg Capsules is not for common skin acne treatment; this capsule strength is used under close blood, liver, and heart monitoring because it can cause significant side effects. It is supplied by Intas Pharmaceuticals Ltd. in a strip/box of 10 capsules.

How it works: Tretinoin works by helping immature leukemia cells in APL mature into more normal cells and then die off instead of multiplying. Because Atranza 10 mg Capsules is swallowed as a capsule, the medicine is absorbed through the digestive tract and then acts on the blood and bone marrow.

Atranza 10 mg Capsules is a higher-strength oral tretinoin product used only when an oncologist has decided this dose is appropriate for the patient’s body size, cancer type, and treatment plan. Unlike lower-dose retinoid products used for other conditions, Atranza 10 mg Capsules is meant for APL treatment and is not something to start on your own or use casually. The 10 mg capsule makes it easier to give the exact prescribed amount in a supervised cancer regimen.

• Acute promyelocytic leukemia (APL)
• Part of induction therapy for APL
• Part of consolidation or combination treatment plans as directed by an oncologist

• Swallow the Atranza 10 mg capsule whole with water; do not open, crush, chew, or dissolve it.
• Take it exactly at the times your oncologist prescribes, because APL dosing is individualized and often given in divided doses.
• Take the capsule with food or soon after meals if your prescriber instructs you to do so, since food can help tolerability.
• Use the exact number of capsules prescribed; do not add extra capsules even if you feel well.
• If you miss a dose, follow your cancer team’s instructions rather than doubling up on your own.
• Handle the capsules carefully and keep them in the original pack until use.

Each Atranza 10 mg Capsules contains 10 mg of tretinoin, so the number of capsules per dose can vary a lot depending on the treatment plan. In APL, the medicine may be taken in divided doses each day, but the exact schedule and maximum daily amount are decided by the prescribing oncologist based on body surface area and safety monitoring. Do not change the dose, frequency, or length of treatment on your own.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Tretinoin may include:

• Headache
• Dry skin or lips
• Mouth irritation or sore mouth
• Nausea or vomiting
• Fever
• Bone or muscle pain
• Raised liver tests or cholesterol levels

• Do not use Atranza 10 mg Capsules in pregnancy; tretinoin can cause serious birth defects.
• Do not breastfeed unless your oncology team specifically says it is safe.
• This is a higher-strength cancer medicine and must be monitored with regular blood tests and clinic visits.
• Tell your doctor right away if you develop fever, shortness of breath, sudden weight gain, or swelling, as these can be emergency symptoms.
• Avoid vitamin A supplements and other retinoid medicines unless your doctor approves them.
• Tell your prescriber about heart disease, high cholesterol, liver disease, or a history of blood clots before starting treatment.
• Use caution with driving or operating machinery if you feel dizzy, have headaches, or have vision changes.

• Tetracycline antibiotics may increase the risk of dangerous pressure inside the skull.
• Vitamin A supplements and other retinoids can increase toxicity.
• Warfarin or other blood thinners may raise bleeding risk and need close monitoring.
• Certain azole antifungals, anticonvulsants, and other cancer medicines may affect treatment or side effects.
• Alcohol may worsen liver-related side effects and should be discussed with your doctor.

Store Atranza 10 mg Capsules in the original strip/box at room temperature, away from moisture, heat, and direct light, and keep it out of reach of children.