Velpanat Tablet 400 mg+100 mg

Velpanat Tablet 400 mg+100 mg is a prescription antiviral medicine that contains sofosbuvir 400 mg and velpatasvir 100 mg in each tablet. It belongs to the direct-acting antiviral class and is used to treat chronic hepatitis C virus (HCV) infection in adults and in some children as directed by a specialist. This fixed-dose tablet is designed to be taken by mouth as part of a complete treatment plan, sometimes with other medicines depending on the HCV type and your medical history.

How it works: Sofosbuvir blocks an HCV enzyme called NS5B polymerase, which the virus needs to make new copies of itself. Velpatasvir blocks another HCV protein called NS5A, and together in this tablet they help stop the virus from multiplying and spreading in the body.

Velpanat Tablet 400 mg+100 mg is the standard fixed-dose tablet strength used in many hepatitis C treatment plans, so it is not a low-dose starter form. Because the dose is already combined in one tablet, a doctor may choose it for patients who are ready for the full prescribed regimen rather than a lower-strength or split-dose option. It is meant to be used exactly as prescribed, not adjusted by the patient based on how they feel.

• Treatment of chronic hepatitis C infection
• Used in adults with HCV genotype 1, 2, 3, 4, 5, or 6 as prescribed
• May be used in people with or without compensated cirrhosis
• May be used after prior hepatitis C treatment failure when directed by a specialist
• Can be part of treatment plans for certain patients with HIV or liver disease under medical supervision

• Swallow the tablet whole with water unless your prescriber gives different instructions.
• Take Velpanat Tablet 400 mg+100 mg at the same time each day.
• You may take it with or without food.
• Do not skip doses, even if you feel well, because hepatitis C can still be present.
• If you miss a dose, follow your prescriber’s instructions or the package directions; do not double up unless told to do so.

Each Velpanat Tablet 400 mg+100 mg provides sofosbuvir 400 mg plus velpatasvir 100 mg in one tablet. It is commonly taken once daily, but the exact duration and whether any other antiviral medicines are needed depends on the doctor’s treatment plan, liver status, and HCV type. The maximum daily dose is one tablet per day unless your clinician specifically instructs otherwise.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sofosbuvir + Velpatasvir may include:

• Headache
• Fatigue
• Nausea
• Trouble sleeping
• Irritability
• Diarrhea

• Tell your doctor if you have hepatitis B, because it can reactivate during or after hepatitis C treatment.
• This is a prescription-strength antiviral tablet, so it should only be used for the exact patient and regimen your doctor selected.
• Use caution if you have significant liver disease or a history of cirrhosis; your prescriber may need monitoring.
• Avoid alcohol or keep it minimal, since alcohol can worsen liver injury.
• Report any history of heart rhythm problems, especially if you take amiodarone or similar medicines.
• Tell your clinician about all medicines and supplements, including seizure medicines, rifampin, St. John’s wort, and acid-reducing drugs.
• Do not use during pregnancy or breastfeeding unless your prescriber says the benefit outweighs the risk.

• Amiodarone
• Rifampin
• Carbamazepine, phenytoin, or phenobarbital
• St. John’s wort
• Certain acid reducers such as antacids, H2 blockers, or proton pump inhibitors

Store Velpanat Tablet 400 mg+100 mg in its original strip/box at room temperature, away from moisture, heat, and direct light.