Combutol 400 mg Tablet

Combutol 400 mg Tablet contains 400 mg of ethambutol in each tablet. It is an antitubercular antibiotic used as part of combination treatment for tuberculosis (TB), not as a medicine for routine bacterial infections. Combutol 400 mg Tablet is prescribed with other TB medicines to help stop the TB bacteria from growing and spreading. Because this is a 400 mg strength, it is often chosen when a doctor wants a single-tablet dose that fits the patient’s weight-based regimen more closely than the 200 mg tablet.

How it works: Ethambutol in Combutol 400 mg Tablet helps block the TB bacteria from building the cell wall they need to survive. This weakens the bacteria so the other TB medicines in the regimen can work better against the infection.

Combutol 400 mg Tablet is a higher-strength ethambutol tablet than Combutol 200 mg Tablet, so it can reduce the number of tablets needed for a prescribed dose. Compared with Combutol 800 mg Tablet, it gives more flexibility for dose adjustment, which is one reason a doctor may choose this strength for adults or older children who need a middle-range amount. The effect does not feel immediate; it works over time as part of a full TB treatment plan.

• Treatment of tuberculosis (TB)
• Part of combination anti-TB therapy
• Helps prevent TB bacteria from multiplying
• Used only with other TB medicines

• Swallow Combutol 400 mg Tablet whole with a full glass of water unless your doctor tells you otherwise.
• Take it at the same time each day to help you stay on schedule with your TB treatment.
• You may take it with or without food; if it upsets your stomach, taking it with food may help.
• Do not skip doses and do not stop early, even if you start feeling better.
• Follow the exact tablet count prescribed, since the 400 mg strength is used to match a specific dose plan.
• If you miss a dose, take it when you remember unless it is close to the next dose; do not double up.

Each Combutol 400 mg Tablet provides 400 mg of ethambutol. The total daily dose and how often you take it depend on your body weight, kidney function, and the other TB medicines in your regimen; your doctor decides the schedule. In many TB regimens, ethambutol is taken once daily, but the maximum daily amount must be set by a clinician for this specific strength and patient.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Ethambutol may include:

• Nausea
• Stomach upset
• Vomiting
• Headache
• Dizziness
• Loss of appetite
• Blurred vision or color vision changes, which can be more concerning with ethambutol and should be reported right away

• Combutol 400 mg Tablet should be used only as part of a multi-drug TB regimen, not by itself.
• Tell your doctor if you have any eye problems, because ethambutol can affect vision.
• People with kidney disease may need a lower dose or closer monitoring because the medicine can build up.
• Avoid alcohol if possible, since it may increase the strain on your liver during TB treatment.
• Do not drive or operate machinery if you notice blurred vision or dizziness.
• Keep all eye exams and follow-up visits, especially if you are on Combutol 400 mg Tablet for more than a short course.
• Tell your clinician about any history of gout, diabetes, or nerve problems before starting treatment.

• Amiodarone or other medicines that can affect vision or the heart rhythm
• Other anti-TB medicines, which are commonly used together and must be managed as a regimen
• Antacids containing aluminum hydroxide, which can reduce absorption if taken too close together
• Kidney-impacting medicines such as aminoglycoside antibiotics, which may raise the risk of side effects
• Alcohol, which can worsen liver-related risk during TB therapy

Store Combutol 400 mg Tablet at room temperature in a dry place, away from excess heat, moisture, and light.