Pyzina 500 mg Tablet

Pyzina 500 mg Tablet contains 500 mg of pyrazinamide in each tablet. It is an antibiotic used as part of combination treatment for active tuberculosis (TB), not as a medicine for common bacterial infections. This Lupin, India tablet is taken by mouth and is used only when a clinician has confirmed TB and selected pyrazinamide as part of the regimen.

How it works: Pyrazinamide works by helping stop TB bacteria from growing and surviving inside the body, especially in the acidic environment where these germs can hide. As a tablet, Pyzina 500 mg Tablet is swallowed and then absorbed into the bloodstream so it can reach the infection sites and work with the other TB medicines.

Pyzina 500 mg Tablet is a standard adult-strength tablet that lets doctors build an exact TB treatment dose using whole tablets. Because pyrazinamide dosing is weight-based and often combined with other TB medicines, this 500 mg strength may be chosen to simplify the number of tablets taken each day and to match the prescribed total dose more closely.

• Active tuberculosis treatment
• Part of combination TB therapy
• Used only under a clinician-prescribed TB regimen
• Helps treat drug-susceptible TB when combined with other medicines

• Swallow Pyzina 500 mg Tablet whole with a full glass of water unless your doctor gives different instructions.
• Take it at the same time each day to help you stay on schedule with TB treatment.
• You may take it with or without food, but food can help if it upsets your stomach.
• Do not change the number of tablets, even if you feel better, unless your prescriber tells you to.
• Take it exactly as part of the full TB combination plan; pyrazinamide should not be used alone.
• If you miss a dose, take it as soon as you remember unless it is almost time for the next dose—do not double up.

Each Pyzina 500 mg Tablet provides 500 mg of pyrazinamide. The number of tablets taken per dose and how often you take them depends on your weight, kidney function, and TB regimen; a doctor decides the schedule for each patient. In many TB treatment plans, pyrazinamide is taken once daily, and the total daily amount is capped by the prescriber based on standard dosing guidance rather than self-adjusted.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Pyrazinamide may include:

• Nausea
• Vomiting
• Loss of appetite
• Stomach upset
• Joint pain or muscle aches
• Mild rash
• Raised liver tests, which may be more concerning at this 500 mg strength if many tablets are used to reach the daily dose

• Use only for TB treatment as prescribed; Pyzina 500 mg Tablet is not for routine infections.
• Tell your doctor if you have liver disease, hepatitis, or a history of heavy alcohol use, because pyrazinamide can stress the liver.
• People with gout, high uric acid, or joint pain need close monitoring because this medicine can raise uric acid.
• Avoid alcohol unless your clinician says it is safe, since alcohol can increase liver risk.
• Let your prescriber know if you have diabetes, kidney disease, or are pregnant or breastfeeding.
• Do not drive or do tasks requiring alertness if you feel weak, dizzy, or unwell after taking it.
• Keep all lab appointments, because liver tests may be needed during treatment.

• Alcohol can increase the risk of liver injury.
• Other TB medicines may be prescribed with it, but the full regimen must be managed by a clinician.
• Medicines or conditions that affect the liver can raise safety concerns when combined with pyrazinamide.
• Gout medicines may need review because pyrazinamide can increase uric acid levels.
• Diabetes medicines may need monitoring if illness or appetite changes affect blood sugar.

Store Pyzina 500 mg Tablet at room temperature in its original strip or box, away from moisture and heat.