Nizol 200 mg Tablet

Nizol 200 mg Tablet is an antifungal medicine that contains 200 mg of ketoconazole in each tablet. It belongs to the azole antifungal class and is used to treat certain serious fungal infections when a doctor decides it is appropriate. Nizol 200 mg Tablet is an oral tablet made by Intas Pharmaceuticals Ltd., supplied in strips/boxes of 10 tablets.

How it works: Ketoconazole works by blocking a fungal enzyme needed to make ergosterol, an important part of the fungal cell membrane. With the membrane damaged, the fungus cannot grow normally and eventually dies or stops spreading.

Nizol 200 mg Tablet is the full tablet strength used when a prescriber wants a 200 mg oral dose rather than a lower-strength option. Because ketoconazole can cause important safety issues, this strength is generally reserved for patients who have been carefully assessed and monitored by a doctor. It may be chosen when a specific tablet dose is needed for the treatment plan.

• Certain fungal infections that need oral treatment
• Yeast-related infections when prescribed by a doctor
• Skin or mucosal fungal infections in specific cases
• Other fungal infections only when the prescriber judges benefit outweighs risk

• Swallow Nizol 200 mg Tablet whole with water; do not crush or chew unless your doctor tells you otherwise.
• Take it exactly as prescribed, since ketoconazole dosing can vary based on the infection and your liver risk.
• Take the tablet with a full meal if your prescriber or pharmacist advises it, because food can improve absorption.
• Do not take antacids, acid reducers, or sucralfate at the same time unless your clinician gives a spacing plan.
• Use the exact schedule your doctor gives you; do not double up doses if you miss one.
• Report any signs of liver problems right away, even if you have been taking the tablet for a short time.

Each Nizol 200 mg Tablet provides 200 mg of ketoconazole. The number of tablets per day depends on the infection and your doctor’s instructions; some regimens use 200 mg once daily, while others may require 200 mg twice daily, but the dose must be individualized. Do not exceed the prescribed amount, because higher exposure can increase the risk of serious side effects.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Ketoconazole may include:

• Nausea
• Vomiting
• Stomach pain or upset stomach
• Diarrhea
• Headache
• Itching or rash
• Dizziness

• Nizol 200 mg Tablet can affect the liver, so people with liver disease need extra caution and monitoring.
• Avoid alcohol or keep intake minimal, since it may add to liver strain and stomach upset.
• This medicine can interact with many drugs, including medicines that affect heart rhythm.
• Tell your doctor about heart disease or a history of abnormal heartbeat before starting treatment.
• Use caution if you take acid-reducing medicines, because they can lower ketoconazole absorption.
• Do not use this tablet during pregnancy or breastfeeding unless your doctor specifically decides the benefit outweighs the risk.
• Be careful with driving or operating machinery if you feel dizzy or weak after taking Nizol 200 mg Tablet.

• Antacids, H2 blockers, proton pump inhibitors, and sucralfate can reduce ketoconazole absorption
• Rifampin can lower ketoconazole levels and reduce effectiveness
• Certain heart rhythm medicines can raise the risk of dangerous QT prolongation
• Some statins, benzodiazepines, and immunosuppressants may interact significantly
• Warfarin and other blood thinners may need close monitoring

Store Nizol 200 mg Tablet in its original strip/box at room temperature, away from moisture, heat, and direct light.