Lioresal 25 Tablet

Lioresal 25 Tablet contains baclofen 25 mg in each tablet. It is a prescription muscle relaxant and antispastic medicine used to help reduce muscle stiffness, tightness, and spasms caused by conditions such as multiple sclerosis, spinal cord disorders, or other neurological problems. Because Lioresal 25 Tablet is a higher-strength baclofen tablet, it is typically used only when a doctor decides a stronger dose is appropriate for the patient.

How it works: Baclofen works by calming overactive nerve signals in the spinal cord that trigger involuntary muscle tightening and spasms. As a tablet, Lioresal 25 Tablet is taken by mouth and is absorbed into the body to help relax muscles over time.

Lioresal 25 Tablet is stronger than Lioresal 10 Tablet, so it is not the usual starting strength for most people. A doctor may choose Lioresal 25 Tablet for patients who need more baclofen to control spasticity, or for those who have already been carefully titrated up from lower strengths and can tolerate the effects.

• Muscle spasm relief
• Spasticity due to multiple sclerosis
• Spasticity from spinal cord injury or disease
• Neurologic muscle tightness
• Painful muscle stiffness related to spasm

• Swallow Lioresal 25 Tablet whole with water unless your doctor tells you otherwise.
• Take it exactly as prescribed; higher-strength baclofen tablets should not be used to self-adjust the dose.
• You may take it with or without food, but taking it with food may help reduce stomach upset.
• Do not crush or split the tablet unless your pharmacist or prescriber says the scored tablet can be divided for your dose.
• Take it at the same times each day to keep a steady effect.
• Do not stop Lioresal 25 Tablet suddenly; your doctor may need to lower the dose gradually.

Each Lioresal 25 Tablet provides baclofen 25 mg per tablet. The dosing schedule varies by the condition being treated and by how you respond; many patients take it multiple times per day, and the doctor decides the exact dose and maximum daily amount. Because this is a higher-strength tablet, it is used as part of a prescribed titration plan rather than as a one-size-fits-all starting dose.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Baclofen may include:

• Drowsiness, which may be more noticeable with the 25 mg strength
• Dizziness
• Weakness or feeling tired
• Nausea
• Headache
• Confusion or lightheadedness

• Lioresal 25 Tablet can cause marked drowsiness, so avoid driving or operating machinery until you know how it affects you.
• Avoid alcohol, which can worsen sedation and dizziness.
• Use extra caution if you have kidney disease, because baclofen can build up in the body.
• Do not stop taking baclofen suddenly, especially at a higher strength, because withdrawal can be serious.
• Tell your doctor if you have a history of seizures, mental health conditions, or breathing problems.
• Older adults may be more sensitive to the effects of Lioresal 25 Tablet, including confusion and falls.
• This strength should only be taken exactly as prescribed; do not take extra tablets for breakthrough spasms.

• Alcohol
• Opioid pain medicines such as oxycodone or hydrocodone
• Benzodiazepines or sleep medicines
• Other sedating medicines, including some antihistamines and muscle relaxants
• Medicines that can increase baclofen effects or side effects, especially other central nervous system depressants

Store Lioresal 25 Tablet at room temperature in the original strip/box, away from moisture and heat, and keep it out of reach of children.