Premarin Vaginal Cream 0.625 mg/14 g

Premarin Vaginal Cream 0.625 mg/14 g is a prescription vaginal cream that contains conjugated estrogens, a type of estrogen hormone medicine. Each tube contains 0.625 mg of conjugated estrogens in 14 g of cream, and it is used to treat menopausal vaginal and urinary symptoms caused by low estrogen. This product is applied locally in the vagina, where it helps relieve dryness, irritation, painful intercourse, and related symptoms. Premarin Vaginal Cream 0.625 mg/14 g is a hormone therapy product and should be used only as directed by a clinician.

How it works: Conjugated estrogens replace some of the estrogen the body makes less of after menopause. In cream form, Premarin Vaginal Cream 0.625 mg/14 g acts directly on vaginal tissue to help restore moisture, thickness, and comfort.

Premarin Vaginal Cream 0.625 mg/14 g is a standard prescription tube strength that allows a doctor to measure treatment carefully for vaginal symptoms. Because estrogen creams can be absorbed through the vaginal lining, a clinician may choose this strength based on symptom severity, exam findings, and how well a lower or less frequent regimen is expected to work.

• Relief of vaginal dryness
• Treatment of vaginal irritation or itching
• Help with painful intercourse due to menopause
• Support for atrophic vaginitis symptoms
• Help with painful urination related to low estrogen

• Use only as prescribed by your doctor; do not use more often or for longer than instructed.
• Insert the cream into the vagina with the applicator provided, following the exact dose markings on the applicator.
• Wash your hands before and after using Premarin Vaginal Cream 0.625 mg/14 g.
• Use it at the time of day your doctor recommends, often at bedtime to reduce leakage.
• If your doctor tells you to use it on a set schedule, keep the timing consistent.
• Do not use this cream by mouth or apply it to the eyes or face.

Each tube of Premarin Vaginal Cream contains 0.625 mg of conjugated estrogens in 14 g of cream. The exact dose and how often you use it are individualized; some patients use it daily for a short period and then less often for maintenance, but the doctor decides the schedule. There is no universal maximum daily amount for all patients because this strength must be tailored to the person and the condition being treated.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Conjugated Estrogens may include:

• Vaginal burning or irritation
• Itching or discharge
• Headache
• Breast tenderness
• Pelvic discomfort
• Nausea
• Fluid retention or bloating

• Do not use if you have unexplained vaginal bleeding unless your doctor has evaluated it.
• Estrogen therapy can increase the risk of blood clots, stroke, and other serious problems in some patients.
• Tell your doctor if you have a history of breast cancer, uterine cancer, liver disease, stroke, or clotting disorders.
• Use caution if you smoke, are overweight, or have high blood pressure, because these can add to cardiovascular risk.
• This cream may not be appropriate if you are pregnant or think you may be pregnant.
• Tell your clinician about any vaginal infections or skin irritation before using the cream.
• Do not share the applicator or use the product more often than prescribed, since higher exposure can raise side effect risk.

• Other estrogen products or hormone therapies
• Tamoxifen or raloxifene
• Blood thinners such as warfarin
• Certain seizure medicines and rifampin, which can affect hormone levels
• Some herbal products such as St. John’s wort

Store Premarin Vaginal Cream 0.625 mg/14 g at room temperature in the original tube, away from heat, and keep the cap tightly closed.