Vagifem 25 mcg Tablet

Vagifem 25 mcg Tablet is a vaginal estradiol tablet used to treat symptoms of menopause caused by low estrogen. Each Vagifem 25 mcg Tablet contains 25 micrograms of estradiol, a form of estrogen hormone. It belongs to the estrogen hormone replacement therapy class and is used to help relieve vaginal dryness, burning, irritation, and painful intercourse related to vaginal atrophy. This product is for vaginal use only and is not the same as oral estrogen tablets.

How it works: Estradiol replaces some of the estrogen the body makes less of after menopause, which helps restore moisture and comfort in the vaginal tissues. As a vaginal tablet, Vagifem 25 mcg Tablet works locally where it is placed to help reduce dryness, thinning, irritation, and pain with sex.

Vagifem 25 mcg Tablet is a higher-strength vaginal estradiol option, so it is typically chosen for patients whose symptoms are significant or who need a doctor-directed treatment plan rather than a lower-dose maintenance approach. Compared with lower-dose vaginal estradiol products, Vagifem 25 mcg Tablet delivers more estrogen per tablet, which may be used when a clinician wants stronger local estrogen support. Because it is a specific higher strength, it should be used exactly as prescribed and not swapped with lower-strength vaginal estrogen tablets without medical advice.

• Vaginal dryness due to menopause
• Vaginal burning or irritation
• Painful intercourse from vaginal atrophy
• Symptoms of vulvar and vaginal thinning after menopause
• Doctor-directed local estrogen therapy

• Use Vagifem 25 mcg Tablet only inside the vagina, not by mouth.
• Insert the tablet with the provided applicator if supplied, following the package directions exactly.
• Take it at the time of day your doctor recommends; many patients use it at bedtime to reduce leakage.
• Do not chew, crush, or swallow the tablet.
• Wash your hands before and after insertion.
• If you miss a dose, follow your prescriber’s instructions rather than doubling up.

Each Vagifem 25 mcg Tablet provides 25 micrograms of estradiol. The exact schedule is decided by your doctor; vaginal estradiol tablets are often used on a set schedule at first and then less often for maintenance, but the prescribed frequency can vary based on symptoms and response. Do not use more tablets per day than your prescriber directs, since this is a higher-strength product.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Estradiol may include:

• Vaginal discharge
• Vaginal itching or irritation
• Pelvic discomfort
• Headache
• Breast tenderness
• Nausea
• Spotting or light bleeding

• Do not use if you have unexplained vaginal bleeding unless your doctor says it is safe to do so.
• Tell your prescriber if you have a history of blood clots, stroke, heart disease, breast cancer, or liver disease.
• Use caution if you smoke, especially if you are older than 35 or have clot risk factors.
• This is a vaginal tablet, so it should not be taken by mouth and should not be used more often than prescribed.
• If you still have a uterus, ask your doctor whether you need any additional hormone therapy.
• Report new vaginal bleeding, breast changes, or severe pelvic pain promptly.
• Tell your doctor if you are pregnant, think you may be pregnant, or are breastfeeding.

• Other estrogen products or hormone therapies
• Aromatase inhibitors such as anastrozole or letrozole
• Certain seizure medicines such as carbamazepine or phenytoin
• Rifampin and some other enzyme-inducing antibiotics
• Herbal products that may affect hormones, including St. John’s wort

Store Vagifem 25 mcg Tablet at room temperature in its original package, away from excess heat, moisture, and direct light.