Difuram 250 mg Tablet

Difuram 250 mg Tablet is a prescription alcohol-use disorder medicine that contains 250 mg of disulfiram in each tablet. It belongs to the disulfiram class of alcohol-deterrent medicines and is used to help people stay away from alcohol as part of a supervised treatment plan. Difuram 250 mg Tablet does not cure alcohol use disorder, but it can support abstinence when taken exactly as prescribed and paired with counseling or other treatment.

How it works: Disulfiram in Difuram 250 mg Tablet blocks an enzyme needed to break down alcohol, so acetaldehyde builds up if alcohol is used. This causes unpleasant reactions that help discourage drinking while the tablet is in your system.

The 250 mg tablet is a higher-strength disulfiram tablet that fits maintenance dosing for people who have already been medically assessed and are ready to avoid alcohol completely. Because there is no lower-strength sibling listed for this brand, Difuram 250 mg Tablet is the specific tablet strength your prescriber may use to match the dose they want and adjust it based on your response and safety.

• Support for alcohol abstinence
• Alcohol use disorder treatment plan
• Deterrent therapy for drinking relapse prevention
• Part of supervised addiction care

• Swallow Difuram 250 mg Tablet by mouth with water unless your doctor tells you otherwise.
• Take it at the same time each day if you are prescribed daily dosing.
• Do not take it until you have been alcohol-free for at least 12 hours, and follow your prescriber’s instructions closely.
• Avoid all alcohol while taking this tablet and for at least 14 days after your last dose.
• Read labels carefully and avoid medicines, mouthwash, cough syrups, tonics, and foods that may contain alcohol.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.

Each Difuram 250 mg Tablet provides 250 mg of disulfiram per tablet. Your doctor decides how often you should take it; some patients take it once daily, and in some supervised treatment plans the dose may be adjusted or given on a schedule tailored by the prescriber. Do not take more than your doctor prescribes, because the correct daily amount and maximum dose depend on your health, alcohol history, and how you tolerate the medicine.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Disulfiram may include:

• Drowsiness or tiredness, which may be more noticeable when treatment is started
• Metallic or garlic-like taste
• Headache
• Nausea or upset stomach
• Skin rash or itching
• Mild dizziness

• Do not drink alcohol of any kind while taking Difuram 250 mg Tablet, including beer, wine, liquor, cooking wine, and alcohol-containing products.
• Avoid alcohol-containing medicines, mouthwashes, aftershaves, and topical products unless your pharmacist or doctor says they are safe.
• Use extra caution if you have heart disease, high blood pressure, diabetes, liver disease, seizure history, or thyroid disease.
• Do not take this tablet if you are intoxicated or have used alcohol recently; wait the full alcohol-free period your doctor recommends.
• This medicine can make you drowsy or dizzy, so use caution when driving or operating machinery until you know how it affects you.
• Tell your doctor if you are pregnant, breastfeeding, or taking medicines for diabetes, depression, infection, or heart rhythm problems.
• Get medical help right away if you have a severe reaction after any alcohol exposure while on this tablet.

• Alcohol, including hidden alcohol in medicines and products
• Metronidazole and similar alcohol-reactive medicines
• Warfarin and other blood thinners
• Phenytoin and some seizure medicines
• Isoniazid and some liver-affecting medicines

Store Difuram 250 mg Tablet at room temperature in the original strip or box, away from moisture and excess heat, and keep it out of reach of children.