Megamentin 375 mg Tablet

Megamentin 375 mg Tablet is an antibiotic that contains amoxicillin 250 mg plus clavulanic acid 125 mg in each tablet. It belongs to the penicillin-type antibiotic group and is used to treat certain bacterial infections, not viral illnesses like colds or flu. Megamentin 375 mg Tablet is prescribed for infections such as sinus, ear, chest, urinary tract, skin, and some dental infections when the bacteria are likely to respond to this combination. Because it contains clavulanic acid, it can work against some bacteria that would otherwise break down amoxicillin.

How it works: Amoxicillin attacks the bacteria by stopping them from building strong cell walls, which helps them die. Clavulanic acid protects amoxicillin from bacterial enzymes that would otherwise inactivate it, so the tablet can work better against resistant germs.

Megamentin 375 mg Tablet is a mid-strength tablet and is different from the higher Megamentin 1000 mg Tablet, which provides a larger antibiotic amount per dose. The 375 mg tablet may suit patients whose infection can be treated with a lower total daily antibiotic exposure, based on a doctor’s assessment and the type of infection. Since this is a prescription-strength combination antibiotic, the right tablet and schedule depend on the infection being treated and the patient’s medical history.

• Sinus infections
• Ear infections
• Chest infections
• Urinary tract infections
• Skin and soft tissue infections
• Dental infections

• Swallow the Megamentin 375 mg Tablet with water; do not crush or chew unless your prescriber specifically says it is okay.
• Take it at the times your doctor prescribes, usually spaced evenly through the day.
• Taking the tablet with food can help reduce stomach upset.
• Finish the full course even if you start feeling better.
• If you miss a dose, take it when you remember unless it is almost time for the next one; do not double up.

Each Megamentin 375 mg Tablet provides a total of 375 mg of antibiotic combination, made up of 250 mg amoxicillin and 125 mg clavulanic acid. How often it is taken can vary, but this strength is often prescribed in divided doses during the day; the exact schedule and the maximum daily amount must be set by the doctor. Do not change the dose or stop early without medical advice, because the right amount depends on the infection and your kidney function.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Amoxicillin + Clavulanic Acid may include:

• Diarrhea
• Nausea
• Vomiting
• Stomach pain
• Mild rash
• Gas or bloating

• Do not use Megamentin 375 mg Tablet if you have a known allergy to amoxicillin, penicillins, or clavulanic acid.
• Tell your doctor if you have had liver problems or antibiotic-associated jaundice, because this combination can affect the liver.
• Use extra caution if you have kidney disease, since dose and timing may need adjustment.
• Take it with food if you get stomach upset, but do not take more often than prescribed.
• Report any rash, hives, breathing trouble, or swelling right away; these can be signs of a serious allergy.
• This tablet can cause diarrhea, and severe diarrhea should be checked promptly rather than self-treated.
• Tell your clinician about all medicines you take, including blood thinners, because interactions may require monitoring.

• Warfarin and other blood thinners
• Methotrexate
• Probenecid
• Allopurinol
• Oral contraceptives, if vomiting or severe diarrhea occurs

Store Megamentin 375 mg Tablet in its original strip or box at room temperature, away from excess heat, moisture, and out of reach of children.