Combimist-L Respules 2.5 mL

Combimist-L Respules 2.5 mL is a prescription asthma and breathing-treatment respule that contains salbutamol (albuterol) plus ipratropium in each 2.5 mL unit. It belongs to the bronchodilator class, with albuterol relaxing tight airway muscles and ipratropium helping keep the airways open. Doctors use Combimist-L Respules 2.5 mL to treat wheezing, shortness of breath, chest tightness, and bronchospasm in conditions such as asthma and COPD-related breathing difficulty. This product is intended for inhalation/nebulization, not for swallowing.

How it works: Albuterol quickly relaxes the muscles around the airways so air can move in and out more easily. Ipratropium blocks signals that cause airway tightening and mucus-related narrowing, and together in Combimist-L Respules 2.5 mL they help open the lungs during a nebulized treatment.

Combimist-L Respules 2.5 mL is a full single-dose respule, so it is different from lower-dose or smaller-volume bronchodilator products because it delivers a fixed amount in one nebulizer treatment. This exact Combimist-L Respules 2.5 mL presentation is typically chosen when a clinician wants a ready-to-use nebulized combination for a patient who needs both quick airway opening and added anticholinergic support.

• Asthma symptoms
• Bronchospasm
• Wheezing
• Shortness of breath
• Chest tightness
• COPD-related airway narrowing

• Use Combimist-L Respules 2.5 mL only in a nebulizer, as directed by your doctor.
• Do not swallow the respule or mix it with other medicines unless your prescriber says to.
• Open the respule right before use and empty the full 2.5 mL into the nebulizer cup.
• Breathe the mist in slowly and deeply through the mouthpiece or mask until the medicine is finished.
• If you need repeated treatments, follow the exact timing your doctor gave you; do not use extra doses on your own.
• If the solution looks discolored or contains particles, do not use it.

Each Combimist-L Respules 2.5 mL unit provides 2.5 mL of nebulized medicine per treatment. The number of treatments per day depends on the condition being treated and your doctor’s instructions; this is not a self-set dosing medicine, and the maximum daily frequency should be set by the prescriber.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Salbutamol / Albuterol + Ipratropium may include:

• Tremor or shakiness
• Nervousness
• Headache
• Dry mouth
• Fast heartbeat or palpitations
• Mild throat irritation after nebulizing
• Cough during or after treatment

• Use caution if you have heart disease, high blood pressure, an abnormal heartbeat, or a history of stroke.
• Tell your doctor if you have glaucoma, enlarged prostate, bladder problems, thyroid disease, diabetes, or seizures.
• This is a nebulized respule, not an oral tablet, so it must be inhaled exactly as directed.
• Overuse can cause stronger side effects such as fast pulse, tremor, and low potassium.
• Avoid getting the mist into your eyes, especially if you have glaucoma or eye pressure problems.
• Ask your clinician before using alcohol if it worsens dizziness or dehydration with your medicines.
• Do not drive if you feel shaky, dizzy, or your vision changes after treatment.

• Other inhaled or oral bronchodilators, including additional albuterol products
• Beta-blockers, which can reduce bronchodilator effect
• Diuretics, which may increase the risk of low potassium
• MAO inhibitors or tricyclic antidepressants, which can increase heart-related side effects
• Other anticholinergic medicines, which can increase dry mouth, constipation, and urinary retention

Store Combimist-L Respules 2.5 mL at room temperature in the original foil or box, protected from light and moisture, and use each respule immediately after opening.