Triluma Cream

Triluma Cream is a prescription skin-lightening and anti-inflammatory cream that contains hydroquinone, tretinoin, and fluocinolone acetonide in the amount labeled on each bottle of Triluma Cream. It combines a depigmenting agent, a retinoid, and a corticosteroid in one cream. Doctors use Triluma Cream to treat short-term facial melasma and other areas of darkened skin when a combination treatment is appropriate.

How it works: Hydroquinone helps reduce the production of melanin, the pigment that makes dark patches look darker. Tretinoin speeds skin cell turnover and fluocinolone acetonide reduces inflammation, so the cream can fade discoloration while limiting irritation from treatment.

Compared with the sibling Triluma RD Cream, Triluma Cream is the standard combination product for patients who need the full triple-ingredient formula in a cream base. It may be chosen when a doctor wants a targeted, once-daily topical option that can work on discoloration while also calming inflammation, but it is not a casual over-the-counter skin cream and should be used exactly as prescribed.

• Short-term treatment of melasma
• Fading dark facial patches
• Combination therapy for hyperpigmentation
• Prescription-only skin discoloration treatment

• Apply a thin layer of Triluma Cream exactly as directed by your doctor, usually to clean, dry affected skin.
• Use it only on the skin; do not swallow it, and avoid contact with eyes, lips, nostrils, and broken or irritated skin.
• Wash your hands before and after applying Triluma Cream unless your hands are the area being treated.
• Apply at night unless your prescriber gives different instructions, since tretinoin can make skin more sun-sensitive.
• Use sunscreen and protective clothing during the day, because this cream can increase sensitivity to sunlight.
• Do not use more often or in a thicker layer than prescribed, because more medicine does not mean better results and can raise irritation risk.

Each labeled bottle of Triluma Cream contains the fixed-strength combination of hydroquinone, tretinoin, and fluocinolone acetonide as specified on the package. It is typically applied once daily in a very thin layer, but the exact amount, duration, and any maximum daily use are determined by the prescriber for the individual patient. This product is not meant for self-directed dosing or long-term continuous use without medical supervision.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Hydroquinone + Tretinoin + Fluocinolone Acetonide may include:

• Skin redness or irritation, which may be more noticeable with this combination cream
• Dryness or peeling
• Burning or stinging after application
• Itching
• Mild skin sensitivity to sunlight
• Temporary worsening of irritation when first starting treatment

• Use only on the areas your doctor told you to treat; do not use it as a general face cream.
• Avoid extra sun exposure and tanning beds, because tretinoin and hydroquinone can increase sun sensitivity.
• Do not apply to cuts, eczema, sunburn, or irritated skin unless your clinician specifically instructs you to do so.
• This product contains a corticosteroid, so prolonged or excessive use can cause skin thinning and other steroid-related effects.
• Tell your prescriber if you are pregnant, trying to become pregnant, or breastfeeding before using Triluma Cream.
• Use caution if you have very sensitive skin or a history of irritation from retinoids, hydroquinone, or topical steroids.
• Do not cover the treated area with tight dressings unless your doctor tells you to, because that can increase absorption and irritation.

• Other topical acne or anti-aging retinoids, which can increase irritation
• Other products containing hydroquinone, tretinoin, or topical corticosteroids
• Astringents, abrasive cleansers, or exfoliating products that can worsen dryness and redness
• Waxing, chemical peels, or harsh cosmetic procedures on the treated area
• Photosensitizing medicines or products that make sun reactions more likely

Store Triluma Cream at room temperature in a tightly closed container, away from excess heat, moisture, and direct light.