Istavel 25 mg Film Coated Tablet

Istavel 25 mg Film Coated Tablet is an oral diabetes medicine that contains 25 mg of sitagliptin in each tablet. It belongs to the DPP-4 inhibitor class and is used to help lower blood sugar in adults with type 2 diabetes, along with diet and exercise. Istavel 25 mg Film Coated Tablet does not treat type 1 diabetes or diabetic ketoacidosis. It is made by Sun Pharmaceutical Industries Ltd. and comes as a strip/box of 10 tablets.

How it works: Sitagliptin in Istavel 25 mg Film Coated Tablet helps the body release more insulin when blood sugar is high and reduces the amount of sugar made by the liver. Because it is a film-coated tablet, you swallow it by mouth and the medicine is absorbed from the digestive tract.

Istavel 25 mg Film Coated Tablet is a lower-strength sitagliptin tablet, and it is commonly chosen when a doctor wants a smaller dose than the usual 100 mg daily dose. This strength is often used in people with reduced kidney function, because sitagliptin dose needs to be lowered when the kidneys do not clear the medicine normally. It should not be treated as a regular starting strength for everyone; the right dose depends on the person's kidney function and treatment plan.

• Type 2 diabetes blood sugar control
• Add-on treatment with diet and exercise
• Dose-adjusted use in kidney impairment
• May be used alone or with other diabetes medicines

• Swallow Istavel 25 mg Film Coated Tablet whole with water; do not chew, crush, or split unless your doctor tells you to.
• Take it at the same time each day if your prescriber has you on a daily schedule.
• It can usually be taken with or without food.
• If you also take insulin or a sulfonylurea, follow your doctor’s instructions closely because low blood sugar can happen more often.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Check your blood sugar as directed and keep follow-up visits so the dose can be adjusted if needed.

Each Istavel 25 mg Film Coated Tablet provides 25 mg of sitagliptin. The exact frequency depends on your kidney function and overall diabetes plan; some patients take it once daily, but the prescriber decides the schedule and whether this lower strength is the right fit. Do not take more than the dose your doctor prescribed, because this strength is intended for dose reduction rather than routine use at higher amounts.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin may include:

• stuffy or runny nose
• sore throat
• headache
• upper respiratory infection symptoms
• nausea
• diarrhea
• low blood sugar if used with insulin or a sulfonylurea

• Tell your doctor if you have kidney disease or are on dialysis, because Istavel 25 mg Film Coated Tablet is often chosen for dose adjustment in that setting.
• Use caution if you also take insulin or a sulfonylurea, since the risk of low blood sugar goes up.
• Get urgent care for signs of pancreatitis, especially persistent severe abdominal pain with or without vomiting.
• Tell your clinician about any history of pancreatitis, kidney problems, or allergic reactions to sitagliptin or similar medicines.
• Avoid alcohol excess, which can make blood sugar harder to control and may raise the risk of low blood sugar.
• Do not use this tablet to treat diabetic ketoacidosis or type 1 diabetes.
• If you feel dizzy or weak from low blood sugar, avoid driving until you feel normal.

• Insulin
• Sulfonylureas such as glipizide or glyburide
• Other diabetes medicines that can lower blood sugar
• Digoxin
• Medicines that affect kidney function or are cleared by the kidneys

Store Istavel 25 mg Film Coated Tablet at room temperature in its original strip/box, away from moisture and excess heat.