Minirin Nasal Spray 2.5 mL

Minirin Nasal Spray 2.5 mL is a desmopressin nasal spray used to treat conditions caused by low levels of antidiuretic hormone, especially central diabetes insipidus and some forms of excessive urination and thirst. Desmopressin is an antidiuretic hormone replacement that helps the body hold on to water and make less urine. This 2.5 mL Minirin Nasal Spray is a prescription medicine, and the exact amount delivered in each spray depends on the device instructions and your prescriber’s directions. It is not a diabetes medicine for blood sugar.

How it works: Desmopressin acts like a natural hormone in the body that tells the kidneys to save water instead of passing it into urine. As a nasal spray, Minirin Nasal Spray 2.5 mL is absorbed through the lining of the nose so it can start reducing urine production without swallowing a tablet.

Minirin Nasal Spray 2.5 mL is a single nasal-spray presentation with no sibling strengths or alternate forms listed here, so your doctor chooses it when a nasal desmopressin option is appropriate for you. Nasal delivery can work quickly compared with some oral options and may be preferred when a patient needs a non-tablet form or when individualized titration is needed. Because desmopressin can cause the body to retain too much water, this product is used only under medical supervision.

• Central diabetes insipidus
• Excessive urination due to low antidiuretic hormone
• Excessive thirst related to diabetes insipidus
• Urine volume control when nasal treatment is preferred

• Use Minirin Nasal Spray 2.5 mL exactly as your doctor prescribed, and do not change the number of sprays on your own.
• Prime and use the spray only the way the patient leaflet or pharmacist instructs, because correct nasal technique affects the dose you receive.
• Blow your nose gently before use if your nose is blocked, and avoid using the spray during a bad cold unless your prescriber says it is okay.
• Do not use more than the prescribed amount; taking extra can raise the risk of water retention and low sodium.
• Limit drinking fluids as directed by your doctor, especially around the time you use the spray.
• If you also use other nasal medicines, separate them as instructed so the spray can be absorbed properly.

This product is Minirin Nasal Spray 2.5 mL, a nasal desmopressin spray prescribed in individualized doses, not a one-size-fits-all daily amount. Depending on your condition, your doctor may tell you to use it once or more than once a day, but the exact frequency and maximum daily amount must come from your prescriber because overuse can cause dangerous water retention and low sodium.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Desmopressin may include:

• Headache
• Nasal congestion or irritation
• Runny nose
• Sneezing
• Mild nausea
• Mild stomach upset

• Do not use if you have a history of low sodium unless your doctor specifically says it is safe.
• Drink only the amount of fluid your prescriber recommends, because too much water can be dangerous with desmopressin.
• Use extra caution if you have heart disease, kidney disease, high blood pressure, or conditions that can be worsened by fluid retention.
• Tell your doctor if you have a stuffy nose, nasal infection, or recent nasal surgery, since this spray may not absorb well.
• Avoid alcohol unless your clinician says it is okay, because alcohol can affect fluid balance and symptom control.
• Do not drive or do tasks requiring alertness if you feel dizzy, weak, or confused.
• Contact your prescriber before using if you are pregnant or breastfeeding so the risks and benefits can be reviewed.

• Diuretics or water pills can increase sodium-related risks and need careful review.
• SSRIs, SNRIs, carbamazepine, and tricyclic antidepressants can raise the risk of low sodium.
• NSAIDs such as ibuprofen or naproxen may increase desmopressin effects and fluid retention.
• Loperamide and other medicines that slow the gut may change desmopressin exposure.
• Other nasal medicines may interfere with absorption or irritation, so timing should be reviewed.

Store Minirin Nasal Spray 2.5 mL at the temperature directed on the package insert, keep it tightly closed, and protect it from heat, freezing, and contamination.