Noctiwin Nasal Spray

Noctiwin Nasal Spray is a prescription desmopressin nasal spray made by Intra Life and supplied as a strip/box of 10 packs. Each Noctiwin Nasal Spray pack contains desmopressin in the labeled spray strength for nasal use, a form of the antidiuretic hormone medicine class. It is used to help reduce excessive urine production and related symptoms in conditions such as central diabetes insipidus, and in some patients it may also be used for bedwetting when a clinician decides a nasal form is appropriate. Because desmopressin can lower urine output and raise the body’s water retention, Noctiwin Nasal Spray must be used exactly as prescribed.

How it works: Desmopressin is a man-made version of vasopressin, a hormone that tells the kidneys to save water instead of making extra urine. As a nasal spray, Noctiwin Nasal Spray is absorbed through the lining of the nose and can help reduce urination and thirst when used as directed.

Noctiwin Nasal Spray is a single labeled spray strength rather than a lower-dose starter tablet or melt form, so it is suited only for patients whose prescriber has specifically chosen the nasal route and dose. Nasal desmopressin can act more directly and may feel faster than an oral form, which is why a doctor may choose Noctiwin Nasal Spray when a spray is preferred or when swallowing tablets is not ideal.

• Central diabetes insipidus
• Reduction of excessive urination
• Nocturnal polyuria in selected patients
• Bedwetting in selected cases if prescribed
• Hormone replacement support for antidiuretic effect

• Use Noctiwin Nasal Spray exactly as your prescriber directs; do not change the dose because the labeled spray strength is not meant for self-adjustment.
• Prime the spray if your package instructions say to do so, then spray into the nostril as instructed while keeping your head in the recommended position.
• Try to use it at the same time each day or at the time your doctor recommends, especially if it is being used for nighttime symptoms.
• Limit drinking fluids before and after the dose unless your doctor tells you otherwise, because too much water can be dangerous with desmopressin.
• Do not use Noctiwin Nasal Spray if you have a blocked nose, severe congestion, or a nose condition that prevents proper absorption without asking your clinician first.
• If you miss a dose, follow your prescriber’s instructions rather than doubling up; taking extra increases the risk of low sodium.

The labeled dose for Noctiwin Nasal Spray is the desmopressin amount stated on the package for each spray pack, and the exact number of sprays per dose depends on the condition being treated. It may be taken once daily or in divided dosing depending on the diagnosis, but the maximum per day must be set by the doctor because the safe dose is individualized for this strength. Do not use more often than prescribed, since too much desmopressin can cause water retention and low sodium.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Desmopressin may include:

• Headache
• Nasal irritation or burning
• Stuffy or runny nose
• Nausea
• Mild stomach discomfort
• Mild dizziness
• Swelling or bloating from fluid retention, which may be more likely if too much fluid is taken

• Follow fluid limits carefully; drinking too much water while using Noctiwin Nasal Spray can cause dangerous low sodium.
• Use extra caution if you are older, since sodium changes and fluid retention can happen more easily.
• Tell your clinician if you have kidney disease, heart failure, uncontrolled high blood pressure, or a history of low sodium.
• Avoid using Noctiwin Nasal Spray during an active nasal infection, heavy congestion, or after recent nasal surgery unless your prescriber says it is okay.
• Alcohol can increase the risk of dehydration or confusion and may make fluid balance harder to manage.
• Do not drive or do anything requiring alertness if you feel dizzy, weak, or mentally foggy after using the spray.
• This is a prescription strength form of desmopressin, so it should only be used by patients who have been assessed by a doctor.

• Other medicines that can lower sodium, including thiazide diuretics and some antidepressants such as SSRIs
• NSAIDs such as ibuprofen or naproxen, which can increase water retention risk
• Carbamazepine or other medicines that may increase antidiuretic effect
• Intranasal decongestants or other nasal products that may interfere with absorption
• Alcohol, which can worsen fluid balance and safety risks

Store Noctiwin Nasal Spray at room temperature in the original container, protected from heat and freezing, and keep the bottle tightly closed when not in use.