Brinzemic-B Eye Drop

Brinzemic-B Eye Drop is a prescription eye drop that contains brinzolamide and brimonidine, with the exact amount listed on the bottle label. It belongs to two glaucoma medicine classes: a carbonic anhydrase inhibitor and an alpha-2 adrenergic agonist. Brinzemic-B Eye Drop is used to lower high pressure inside the eye, including pressure from open-angle glaucoma or ocular hypertension. By reducing eye pressure, it may help protect the optic nerve and preserve vision.

How it works: Brinzolamide lowers fluid production inside the eye, which helps reduce pressure. Brimonidine also lowers eye pressure by decreasing fluid made in the eye and helping fluid drain better, and this works directly where the eye drop is placed.

Brinzemic-B Eye Drop is an as-labelled combination eye drop, so the exact bottle strength is chosen by a clinician rather than self-selected. Compared with lower single-ingredient options, this fixed-combination form is suited for patients who need pressure control from two different mechanisms in one eye drop. A doctor may choose Brinzemic-B Eye Drop when a stronger or more convenient combination approach is needed, while still using only the exact strength printed on the bottle.

• Open-angle glaucoma
• Ocular hypertension
• Lowering raised intraocular pressure
• Protecting the optic nerve from pressure damage

• Use Brinzemic-B Eye Drop exactly as your eye doctor prescribed; do not change the dose on your own.
• Wash your hands before using the bottle and avoid touching the dropper tip to your eye, fingers, or any surface.
• Tilt your head back, pull down the lower eyelid, and place the prescribed number of drops into the eye.
• If you use other eye medicines, wait at least 5 to 10 minutes between products unless your doctor gives different instructions.
• After putting in the drop, close your eye gently and press the inner corner of the eye for about 1 minute to reduce drainage into the nose.
• Remove contact lenses before using the drops and wait to put them back in unless your eye doctor says it is okay.

Brinzemic-B Eye Drop provides brinzolamide + brimonidine in the exact strength listed on the label of each bottle; the dose is not meant to be guessed or adjusted on your own. It is commonly used as 1 drop in the affected eye(s) twice daily, but the actual schedule depends on the prescriber and the label directions for this specific strength. Do not use more often than prescribed, because the maximum daily dose is set by your doctor based on your eye pressure and response.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Brinzolamide + Brimonidine may include:

• Blurred vision right after instilling the drop
• Eye redness or irritation
• Eye itching or burning
• Bitter or unusual taste in the mouth
• Dry mouth
• Headache
• Sleepiness or fatigue

• Brinzemic-B Eye Drop can cause temporary blurred vision or drowsiness, so be careful driving until you know how it affects you.
• Use caution if you have asthma, COPD, heart disease, low blood pressure, depression, or poor circulation.
• Tell your doctor if you have kidney disease, because brinzolamide can be more risky when kidney function is reduced.
• Do not use if you are allergic to sulfonamide medicines, brinzolamide, brimonidine, or any bottle ingredient unless your clinician says it is safe.
• Avoid wearing contact lenses during dosing unless your eye doctor has told you otherwise.
• Alcohol or other medicines that cause sleepiness can make dizziness and drowsiness worse.
• If you become pregnant or are breastfeeding, ask your doctor before using Brinzemic-B Eye Drop.

• MAO inhibitors may interact with brimonidine and increase side effects.
• Tricyclic antidepressants can reduce the effect of brimonidine or increase blood pressure effects.
• Other eye pressure medicines may add to the pressure-lowering effect and side effects.
• Medicines that cause drowsiness, including alcohol, opioids, or sleep aids, may worsen sedation and dizziness.
• Oral carbonic anhydrase inhibitors such as acetazolamide can increase carbonic anhydrase–related side effects.

Store Brinzemic-B Eye Drop at the temperature listed on the package insert, keep the bottle tightly closed, and protect it from contamination; do not freeze unless the label says otherwise.