Zonat (Natamycin) 5% 5 mL Eye Drop

Zonat (Natamycin) 5% 5 mL Eye Drop is an antifungal eye medicine used to treat fungal infections of the eye, especially fungal keratitis and other susceptible fungal infections on the eye’s surface. Each 5 mL bottle contains natamycin 5%, a polyene antifungal that works locally in the eye. It is typically prescribed when a doctor has confirmed or strongly suspects a fungal cause and wants treatment delivered directly to the affected eye.

How it works: Natamycin binds to fungal cell membranes and disrupts their structure, which stops the fungus from growing and can help clear the infection. As an eye drop, it delivers the medicine right where the fungus is affecting the cornea or eye surface.

Zonat (Natamycin) 5% 5 mL Eye Drop is a higher-strength ophthalmic antifungal, so it is intended for use only when an eye specialist has assessed the infection and chosen this formulation. Because it is used directly in the eye rather than by mouth, it acts at the infection site with little systemic exposure, but the exact schedule and duration still depend on how severe the infection is and how your eye responds.

• Fungal keratitis
• Fungal eye infection on the cornea
• Suspected fungal infection of the eye surface
• Treatment directed by an eye doctor for susceptible fungi

• Wash your hands before using Zonat (Natamycin) 5% 5 mL Eye Drop.
• Tilt your head back, pull down the lower eyelid, and place the prescribed number of drops into the affected eye.
• Do not touch the dropper tip to your eye, fingers, or any surface.
• Close the eye gently for 1 to 2 minutes after instilling the drop; do not rub the eye.
• If you use other eye medicines, wait at least 5 to 10 minutes between products unless your doctor tells you otherwise.
• Replace the cap tightly after use and use only as long as your doctor prescribes.

Each bottle of Zonat (Natamycin) 5% 5 mL Eye Drop contains natamycin 5% for ophthalmic use, and the number of drops per dose is decided by the doctor. It is commonly used multiple times a day at the start of treatment for fungal eye infections, but there is no single maximum daily dose for everyone because the schedule depends on the infection and your response. Follow your eye doctor’s instructions exactly and do not stop early even if the eye starts feeling better.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Natamycin may include:

• Temporary eye irritation or burning after instillation
• Mild stinging or pain in the eye
• Redness of the eye
• Blurred vision for a short time after use
• Watery eyes
• Foreign-body sensation or eye discomfort

• Use only in the eye; do not swallow the eye drops.
• Remove contact lenses before use unless your eye doctor says otherwise.
• Do not wear contact lenses during an active eye infection unless specifically approved by your doctor.
• Vision may be blurred right after dosing, so be careful driving or using machinery until it clears.
• Tell your doctor if you have had allergy or irritation with natamycin or other eye medicines.
• Do not use the bottle if the solution is discolored, contaminated, or past the expiration date.
• Complete the full course even if symptoms improve, because fungal eye infections can return if treatment is stopped too soon.

• Other prescription eye drops or ointments, which may need to be spaced several minutes apart
• Contact lens solutions or rewetting drops during an active infection, unless approved by your doctor
• Other antifungal eye treatments, if prescribed together by an eye specialist
• Eye medications containing preservatives that may increase irritation when used at the same time

Store Zonat (Natamycin) 5% 5 mL Eye Drop at room temperature, tightly closed, and keep it away from heat, freezing, and direct light.