Starstat EZ 20 mg/10 mg Tablet

Starstat EZ 20 mg/10 mg Tablet is a prescription combination medicine that contains simvastatin 20 mg and ezetimibe 10 mg in each tablet. It belongs to the cholesterol-lowering medicine class and is used to help lower LDL (“bad”) cholesterol and triglycerides while raising HDL (“good”) cholesterol when diet and exercise alone are not enough. Starstat EZ 20 mg/10 mg Tablet is used in people who need a stronger lipid-lowering option than the lower-strength Starstat EZ 10 mg/10 mg Tablet. It is not a quick-relief medicine and works best when taken regularly as prescribed.

How it works: Simvastatin in this tablet helps reduce the liver’s production of cholesterol, which lowers the amount of LDL cholesterol circulating in the blood. Ezetimibe blocks cholesterol absorption from the intestine, so together the tablet lowers cholesterol from two different pathways.

Starstat EZ 20 mg/10 mg Tablet provides a higher statin dose than Starstat EZ 10 mg/10 mg Tablet while keeping ezetimibe at 10 mg, so it may be chosen when a doctor wants more LDL-lowering effect. This higher-strength tablet is meant for patients who have already been assessed for cholesterol goals, response, and side effect risk; it is not the usual first step for everyone.

• High LDL cholesterol
• Mixed dyslipidemia
• Reducing total cholesterol
• Adjunct to diet and exercise
• Cardiovascular risk reduction in appropriate patients

• Swallow the tablet whole with water; do not crush, chew, or split it unless your prescriber tells you to.
• Take it exactly at the time your doctor recommends; simvastatin-containing tablets are often taken in the evening.
• You can take the tablet with or without food.
• Keep taking it even if you feel well, because cholesterol problems usually do not cause symptoms.
• Follow a cholesterol-lowering diet and exercise plan while using Starstat EZ 20 mg/10 mg Tablet.
• Avoid grapefruit and grapefruit juice unless your clinician says it is okay.

Each Starstat EZ 20 mg/10 mg Tablet contains 20 mg simvastatin and 10 mg ezetimibe. The tablet is usually taken once daily, and the exact dose, timing, and treatment length are decided by the doctor based on your cholesterol levels, medical history, and other medicines. Do not take more than one tablet in 24 hours unless your prescriber specifically instructs you to do so.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Simvastatin + Ezetimibe may include:

• Headache
• Muscle aches or mild muscle pain
• Diarrhea
• Abdominal pain
• Nausea
• Upper respiratory symptoms
• Mild fatigue

• This is a higher-strength cholesterol tablet, so the doctor should confirm it is appropriate before you start it.
• Tell your prescriber if you have liver disease, kidney disease, or a history of muscle problems.
• Avoid heavy alcohol use, which can increase the risk of liver injury.
• Do not use during pregnancy, and do not breastfeed unless your clinician says it is safe.
• Report any unexplained muscle pain right away, because statins can rarely cause serious muscle injury.
• Let your doctor know about all other medicines and supplements, especially if you already take cholesterol-lowering drugs.
• Use caution when driving if you feel dizzy or weak after taking it.

• Strong CYP3A4 inhibitors such as clarithromycin, itraconazole, or ketoconazole
• Grapefruit or grapefruit juice
• Cyclosporine, danazol, or certain HIV/HCV medicines
• Other lipid-lowering medicines, especially fibrates or high-dose niacin

Store Starstat EZ 20 mg/10 mg Tablet in its original strip/box at room temperature, away from moisture, heat, and light.