Prostium E 0.06% Gel

Prostium E 0.06% Gel is a prescription estradiol gel for women’s health that delivers estradiol through the skin. Each tube contains estradiol 0.06%, a form of estrogen used to treat symptoms caused by low estrogen levels, including menopausal symptoms and some estrogen-deficiency conditions. As an estradiol gel, Prostium E 0.06% Gel is absorbed through the skin rather than taken by mouth. It should be used exactly as prescribed by a clinician who has decided this strength is appropriate for you.

How it works: Estradiol replaces or supplements the estrogen your body is not making enough of, which can help reduce symptoms linked to low estrogen. In gel form, Prostium E 0.06% Gel is applied to the skin so the medicine is absorbed into the bloodstream without swallowing a pill.

Prostium E 0.06% Gel is a concentrated estradiol gel strength, so it is meant for patients whose doctor has assessed that this specific dose level is needed. Compared with lower-dose estradiol gels, the 0.06% strength may deliver more hormone per application, so it is not a starter product for everyone and may be chosen when a clinician wants a stronger or more tailored estrogen effect. Because it is a topical gel, it can be absorbed relatively steadily when used correctly, but the exact amount and schedule still depend on the prescription.

• Relief of menopausal hot flashes
• Treatment of vaginal dryness and menopause-related symptoms
• Management of low-estrogen states as prescribed
• Support for hormone replacement therapy when a clinician recommends estrogen
• Symptom control related to estrogen deficiency

• Apply Prostium E 0.06% Gel only to the skin area and amount your doctor prescribed.
• Use clean, dry, intact skin; do not apply to breasts, face, or irritated skin unless told otherwise.
• Wash your hands after applying the gel unless the hands are the treatment site.
• Let the gel dry completely before dressing or touching others.
• Avoid bathing, swimming, or washing the application area until the gel has had time to absorb, as directed by your prescriber.
• Do not use more tubes or more frequent applications than prescribed, even if symptoms are not fully controlled.

Each tube of Prostium E 0.06% Gel provides estradiol 0.06%, which is a higher-strength estradiol gel that should be used only under a doctor’s direction. The application frequency may be once daily or another schedule chosen by your clinician, and the maximum daily amount depends on your prescription and treatment goals. Do not change the dose on your own, because the right amount varies based on your symptoms, response, and safety factors.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Estradiol may include:

• Skin irritation or redness where the gel is applied
• Headache
• Breast tenderness
• Nausea
• Bloating
• Mood changes
• Spotting or breakthrough bleeding

• Do not use Prostium E 0.06% Gel if you have unexplained vaginal bleeding unless your prescriber has evaluated it.
• Estradiol can raise the risk of blood clots, stroke, and heart problems in some patients, especially with certain risk factors.
• Tell your clinician if you have a history of breast cancer, uterine cancer, blood clots, stroke, liver disease, or heart disease.
• If you have a uterus, your clinician may also prescribe a progestin to help protect the uterine lining.
• Avoid smoking, since it can increase estrogen-related cardiovascular risks.
• Keep the gel away from children and pets until fully dry and stored safely.
• Do not apply heat directly over the treated area unless your prescriber says it is okay, because this can affect absorption.

• Blood thinners such as warfarin
• Thyroid hormone medicines
• Rifampin and some other enzyme-inducing drugs
• Certain anti-seizure medicines such as carbamazepine or phenytoin
• Herbal products like St. John’s wort

Store Prostium E 0.06% Gel at room temperature, away from excess heat, moisture, and direct sunlight, and keep the tubes tightly closed in the original box of 10 tubes.