Amlosafe 5 Tablet

Amlosafe 5 Tablet is an oral tablet containing amlodipine 5 mg in each tablet. It belongs to the calcium channel blocker class and is used to treat high blood pressure and certain types of chest pain (angina). By helping relax blood vessels, Amlosafe 5 Tablet can make it easier for the heart to pump blood. This specific 5 mg strength is a standard prescription dose, not a starting strength for everyone.

How it works: Amlodipine in Amlosafe 5 Tablet blocks calcium from entering muscle cells in blood vessel walls, which helps the vessels relax and widen. With the vessels open more easily, blood pressure can come down and the heart may need less oxygen when treating angina.

Amlosafe 5 Tablet contains 5 mg of amlodipine per tablet, which is stronger than Amlosafe 2.5 Tablet. Doctors may choose Amlosafe 5 Tablet for people who need a standard maintenance dose or who did not get enough benefit from the lower 2.5 mg strength. Because it is a higher strength than 2.5 mg, it should be used only when a clinician has assessed that this dose is appropriate.

• High blood pressure (hypertension)
• Stable angina
• Vasospastic angina
• Long-term blood pressure control

• Swallow the Amlosafe 5 Tablet whole with water.
• Take it once daily or exactly as your doctor prescribes.
• You can take it with or without food.
• Try to take it at the same time each day for steady effect.
• Do not crush or chew unless your doctor or pharmacist specifically tells you to.
• If you miss a dose, take it when you remember unless it is close to the next dose; do not double up.

Each Amlosafe 5 Tablet provides amlodipine 5 mg. For most adults, it is taken once daily, and the doctor decides the exact dose based on blood pressure, symptoms, age, and other medicines. Do not take more than the prescribed amount; the usual maximum adult daily dose of amlodipine is 10 mg.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Amlodipine may include:

• Swelling of the ankles or feet, which may be more noticeable at the 5 mg strength
• Dizziness
• Flushing
• Headache
• Fatigue
• Palpitations
• Nausea

• Use extra caution if you have heart failure, a recent heart attack, or severe aortic stenosis.
• This medicine can cause dizziness, especially when you first start or when the dose is increased.
• Alcohol may worsen dizziness or lightheadedness.
• Tell your doctor if you have liver disease, because amlodipine may need closer monitoring.
• If you already take other blood pressure medicines, the combination may lower your pressure too much.
• Do not stop this medicine suddenly without medical advice, especially if it is being used for angina.
• Use caution when driving or operating machinery until you know how Amlosafe 5 Tablet affects you.

• Other blood pressure medicines, which can increase the risk of low blood pressure
• Nitrates used for chest pain, which may further lower blood pressure
• Simvastatin, because amlodipine can increase simvastatin exposure
• Strong CYP3A4 inhibitors such as clarithromycin, itraconazole, or ritonavir
• Grapefruit or grapefruit juice, which may increase amlodipine levels

Store Amlosafe 5 Tablet at room temperature in the original strip/box, away from moisture and excessive heat.