Pletoz 100 mg Tablet

Pletoz 100 mg Tablet contains cilostazol 100 mg in each tablet. It is a prescription phosphodiesterase-3 inhibitor used to improve walking distance in people with intermittent claudication, a symptom of peripheral artery disease (PAD) that causes leg pain or cramping with walking. Pletoz 100 mg Tablet helps reduce the leg pain caused by poor blood flow, but it does not cure PAD. It is a higher-strength tablet that a clinician may choose after assessing whether 100 mg dosing is appropriate for the patient.

How it works: Cilostazol in Pletoz 100 mg Tablet works by relaxing blood vessels and reducing platelet clumping, which helps blood flow better through narrowed arteries. As a tablet, it is taken by mouth and is absorbed into the body to help improve walking ability over time.

Pletoz 100 mg Tablet is the higher-strength option compared with Pletoz 50 mg Tablet. Doctors may choose Pletoz 100 mg Tablet for patients who need the standard full cilostazol dose and can tolerate it, while the 50 mg strength may be used when a lower dose is needed because of side effects, interactions, or other clinical factors. This strength is not a faster-acting version; it is the same medicine in a stronger tablet.

• Intermittent claudication
• Peripheral artery disease (PAD) symptoms
• Leg pain or cramping with walking
• Improving walking distance

• Swallow Pletoz 100 mg Tablet whole with water; do not crush or chew it.
• Take it exactly as prescribed, usually twice daily, about 30 minutes before or 2 hours after breakfast and dinner.
• Take it on an empty stomach, because food can change absorption and side effects.
• If a dose is missed, take it when remembered unless it is close to the next dose; do not double up.
• Use the 100 mg tablet only if your prescriber specifically selected this strength for you.
• Keep taking it regularly to get the intended benefit; it is not meant for sudden pain relief.

Each Pletoz 100 mg Tablet provides 100 mg of cilostazol. For intermittent claudication, the usual regimen with this strength is one tablet twice daily, but your doctor decides the exact dosing based on your health and other medicines. The maximum usual total dose is 200 mg per day, and the 100 mg tablet is the full adult dose used when appropriate.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Cilostazol may include:

• Headache
• Diarrhea
• Dizziness
• Palpitations or fast heartbeat
• Nausea
• Abdominal pain
• Swelling of the ankles or legs

• Do not use Pletoz 100 mg Tablet if you have heart failure.
• Tell your doctor if you have a history of bleeding problems or stomach ulcers.
• Avoid this medicine if you are taking strong CYP3A4 or CYP2C19 inhibitors unless your prescriber says otherwise.
• Use caution if you have liver or kidney disease, since the 100 mg strength may not be suitable for everyone.
• Report any unusual bruising, nosebleeds, or blood in the stool right away.
• Be careful driving or operating machinery if you feel dizzy or lightheaded.
• Do not use it for chest pain emergencies; it is not a rescue medicine.

• Warfarin and other blood thinners
• Aspirin, clopidogrel, and other antiplatelet medicines
• Ketoconazole, itraconazole, erythromycin, clarithromycin, fluconazole, diltiazem, and similar inhibitors
• Rifampin and other strong enzyme inducers
• Grapefruit products may increase cilostazol levels

Store Pletoz 100 mg Tablet in its original strip or box at room temperature, away from moisture, heat, and direct light.