Pletoz 50 mg Tablet

Pletoz 50 mg Tablet is a prescription medicine that contains 50 mg of cilostazol in each tablet. Cilostazol is a phosphodiesterase-3 (PDE3) inhibitor used to improve walking distance in people with intermittent claudication caused by peripheral artery disease. Pletoz 50 mg Tablet is the lower-strength tablet in this brand’s range and is chosen when a doctor wants a lower cilostazol dose or a more cautious starting approach. It is not a pain reliever in the usual sense; it works on blood flow and leg symptoms related to poor circulation.

How it works: Cilostazol helps the blood vessels widen and makes platelets less sticky, which can improve blood flow through narrowed arteries. In tablet form, Pletoz 50 mg Tablet delivers this medicine by mouth so it can help reduce leg pain or cramping with walking over time.

Pletoz 50 mg Tablet is the lower-strength option compared with Pletoz 100 mg Tablet. Doctors may choose this strength for people who need a smaller dose, have side effects with higher doses, or need a cautious dose adjustment because of other medicines or health conditions. Because it is the 50 mg tablet, it may be better suited for patients who should not begin at the higher 100 mg strength.

• Intermittent claudication
• Peripheral artery disease symptoms
• Improving walking distance
• Blood flow support in narrowed leg arteries

• Take Pletoz 50 mg Tablet by mouth with water, exactly as prescribed.
• It is usually taken twice daily, 30 minutes before or 2 hours after meals, because food can affect absorption.
• Swallow the tablet whole; do not crush, chew, or split unless your doctor tells you to.
• Take it consistently at the same times each day to help you remember doses.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Keep taking it even if you do not feel an immediate effect, since symptom improvement can take time.

Each Pletoz 50 mg Tablet provides 50 mg of cilostazol. The dose is commonly taken twice daily, but the exact schedule and whether the dose is right for you are decided by your doctor; the usual maximum for cilostazol is 100 mg twice daily, and Pletoz 50 mg Tablet is the lower-strength option used when a smaller dose is needed.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Cilostazol may include:

• Headache
• Diarrhea
• Dizziness
• Palpitations or fast heartbeat
• Abdominal discomfort
• Nausea

• Do not use Pletoz 50 mg Tablet if you have heart failure; cilostazol carries a boxed warning for this condition.
• Tell your doctor if you have any heart disease, irregular heartbeat, or a history of chest pain.
• Use caution if you take blood thinners or antiplatelet medicines, because bleeding risk may increase.
• Avoid taking it with strong CYP3A4 or CYP2C19 inhibitors unless your doctor adjusts treatment.
• Alcohol may worsen dizziness or headache in some people.
• Be careful driving or using machines if the tablet makes you dizzy or lightheaded.
• Tell your doctor about pregnancy, breastfeeding, or planned surgery before starting this medicine.

• Omeprazole and other CYP2C19 inhibitors
• Ketoconazole, erythromycin, and other strong CYP3A4 inhibitors
• Aspirin, clopidogrel, warfarin, and other blood-thinning medicines
• Grapefruit or grapefruit juice
• Other medicines that can affect heart rhythm

Store Pletoz 50 mg Tablet in its original strip/box at room temperature, away from moisture, heat, and direct light.