Zotrim SS 400 mg/80 mg Tablet

Zotrim SS 400 mg/80 mg Tablet is a prescription antibiotic tablet containing sulfamethoxazole 400 mg and trimethoprim 80 mg in each tablet. It belongs to the sulfonamide/antifolate antibiotic combination used to treat certain bacterial infections. Doctors may prescribe Zotrim SS 400 mg/80 mg Tablet for infections such as urinary tract infections, ear infections, bronchitis, traveler’s diarrhea, and some skin infections when the bacteria are likely to respond to this combination.

How it works: Sulfamethoxazole and trimethoprim work together by blocking two separate steps bacteria need to make folate, a vitamin-like substance they need to grow and multiply. In tablet form, Zotrim SS 400 mg/80 mg provides a fixed-dose combination that reaches the bloodstream after swallowing and helps clear susceptible bacteria from the body.

Zotrim SS 400 mg/80 mg Tablet is a standard single-tablet strength, not a low-dose form for very small pediatric dosing. Because each tablet contains 400 mg sulfamethoxazole and 80 mg trimethoprim, it is often chosen when a clinician wants a convenient oral strength that can be taken in multiple doses per day for a full treatment course. The exact schedule depends on the infection, kidney function, age, and response to treatment.

• Urinary tract infections
• Middle ear infections
• Bronchitis and some respiratory infections
• Traveler’s diarrhea caused by susceptible bacteria
• Certain skin and soft tissue infections

• Swallow Zotrim SS 400 mg/80 mg Tablet whole with a full glass of water.
• Take it exactly as prescribed, at evenly spaced times.
• You may take it with food or milk if it upsets your stomach.
• Drink plenty of fluids during treatment unless your doctor tells you to limit fluids.
• Finish the full course even if you start feeling better.
• Do not double up doses if you miss one; take the next dose at the usual time.

Each Zotrim SS 400 mg/80 mg Tablet provides 400 mg sulfamethoxazole plus 80 mg trimethoprim. The number of tablets per dose and how often you take them can vary widely by infection; many regimens use more than one tablet per day, while the maximum daily amount must be set by your doctor based on the condition being treated and kidney function. Do not adjust the dose on your own, because this strength is meant to be used within a doctor-selected schedule.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sulfamethoxazole + Trimethoprim may include:

• Nausea
• Vomiting
• Loss of appetite
• Mild diarrhea
• Headache
• Skin rash or itching
• Increased sensitivity to sunlight

• This is a prescription antibiotic and should only be used for bacterial infections that your doctor has assessed.
• Tell your doctor if you have a sulfa allergy, a history of severe drug rash, or reactions to trimethoprim-sulfamethoxazole.
• Use caution if you have kidney disease, liver disease, folate deficiency, or a history of blood disorders.
• Stay hydrated unless instructed otherwise, because this medicine can sometimes affect the kidneys.
• Avoid excessive sun exposure and use sun protection, since this tablet can increase sun sensitivity.
• Tell your clinician if you are pregnant, planning pregnancy, or breastfeeding.
• Use caution when driving if you feel dizzy, weak, or unwell after taking it.

• Warfarin and other blood thinners
• ACE inhibitors, ARBs, and potassium-sparing diuretics
• Methotrexate
• Phenytoin
• Sulfonylurea diabetes medicines

Store Zotrim SS 400 mg/80 mg Tablet in its original strip or box at room temperature, away from moisture and heat.