CO-Trimoxazole Double Strength Tablet

CO-Trimoxazole Double Strength Tablet is an antibiotic tablet containing sulfamethoxazole and trimethoprim in the double-strength amount, with each tablet providing 800 mg sulfamethoxazole plus 160 mg trimethoprim. It belongs to the sulfonamide/folate-antagonist antibiotic class and is used to treat certain bacterial infections, not viral illnesses like colds or flu. CO-Trimoxazole Double Strength Tablet is commonly prescribed for infections such as urinary tract infections, some respiratory infections, ear infections, and certain skin or gastrointestinal infections when the bacteria are susceptible. This Cadila Pharmaceuticals tablet is a full-strength tablet designed for patients who need the higher-strength formulation.

How it works: Sulfamethoxazole and trimethoprim work together to block two steps that bacteria need to make folic acid, which helps stop bacteria from growing and multiplying. In the tablet form of CO-Trimoxazole Double Strength Tablet, this combination is absorbed after swallowing and then works throughout the body against susceptible bacteria.

CO-Trimoxazole Double Strength Tablet is the higher-strength tablet form, so it delivers more medicine per tablet than single-strength products and may be chosen to reduce the number of tablets taken each day. Because it is a double-strength tablet, it is generally used only when a clinician has decided this strength is appropriate for the infection, the patient’s age, kidney function, and overall health.

• Urinary tract infections
• Some ear infections
• Some respiratory tract infections
• Certain skin infections
• Some gastrointestinal infections
• Selected infections caused by susceptible bacteria

• Swallow CO-Trimoxazole Double Strength Tablet whole with a full glass of water unless your doctor tells you otherwise.
• Take it at evenly spaced times each day to keep the antibiotic level steady.
• You may take it with food or milk if it upsets your stomach.
• Drink extra fluids while taking this tablet unless your doctor has told you to limit fluids.
• Finish the full course exactly as prescribed, even if you start feeling better before it is done.

Each CO-Trimoxazole Double Strength Tablet contains 800 mg sulfamethoxazole and 160 mg trimethoprim. The medicine is often taken twice daily for many infections, but the exact dose, frequency, and total daily maximum depend on the infection being treated and the patient’s kidney function, age, and other factors. Your doctor decides whether this double-strength tablet is the right dose for you and how many tablets per day are safe.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sulfamethoxazole + Trimethoprim may include:

• Nausea
• Vomiting
• Loss of appetite
• Diarrhea
• Mild rash
• Headache
• Dizziness

• Do not use CO-Trimoxazole Double Strength Tablet if you have a serious sulfonamide allergy unless a doctor specifically says it is safe.
• This higher-strength tablet may need extra caution in people with kidney problems because dose adjustment may be required.
• Stay well hydrated, since this medicine can sometimes affect the kidneys and cause crystalluria if fluid intake is low.
• Use caution if you have liver disease, folate deficiency, anemia, or are older and medically frail.
• Tell your doctor if you take warfarin or other blood thinners, because bleeding risk can increase.
• Some people become more sensitive to sunlight while taking this antibiotic, so limit strong sun exposure and use protection.
• Do not use it to treat a cold, flu, or other viral illness, because it will not help.

• Warfarin and other blood thinners
• ACE inhibitors or ARBs and potassium-sparing diuretics, which can raise potassium
• Methotrexate, which can increase toxicity risk
• Phenytoin, which may have increased levels
• Dofetilide, which is generally contraindicated with trimethoprim-sulfamethoxazole

Store CO-Trimoxazole Double Strength Tablet in its original strip or box at room temperature, away from moisture, heat, and direct light.