Glynase-MF Tablet

Glynase-MF Tablet is an oral antidiabetic medicine that combines glipizide and metformin in each tablet as labelled by the manufacturer, USV, India. It belongs to two diabetes drug classes: a sulfonylurea (glipizide) and a biguanide (metformin). Glynase-MF Tablet is used to help lower blood sugar in adults with type 2 diabetes when diet and exercise alone are not enough. It is not used to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Glipizide helps your pancreas release more insulin, which lowers blood sugar after meals and throughout the day. Metformin helps your body use insulin better and reduces the amount of sugar made by the liver, making this tablet work in two ways to control blood glucose.

This Glynase-MF Tablet strength is the exact fixed-dose tablet your doctor may choose when both glipizide and metformin are needed together in one tablet. Because it contains a higher-potency combination than a single-ingredient tablet, it is meant for people whose diabetes plan has already been assessed and adjusted by a clinician. The tablet form is taken by mouth with water and is intended for regular daily use, not for rapid sugar correction.

• Type 2 diabetes blood sugar control
• Adjunct to diet and exercise
• Combination therapy when one medicine is not enough
• Helps improve fasting and post-meal glucose levels

• Swallow the Glynase-MF Tablet whole with water; do not crush, chew, or split unless your prescriber says it is okay.
• Take it exactly as prescribed, usually with meals or shortly before meals to reduce stomach upset and help lower low blood sugar risk.
• Take it at the same time each day to keep blood sugar control more even.
• If you miss a dose, follow your prescriber’s instructions; do not double up to make up for a missed tablet.
• Keep a quick source of sugar with you in case of hypoglycemia, since glipizide can lower blood sugar too much.
• Limit or avoid alcohol unless your doctor says it is safe, because alcohol can increase metformin-related risks and affect glucose levels.

Each Glynase-MF Tablet contains the labeled fixed dose of glipizide plus metformin in one tablet, so the amount of each ingredient is not flexible within the tablet. The doctor decides how often to take it based on your blood sugar, kidney function, and response to treatment; some patients take it once daily and others may need divided dosing depending on the prescribed regimen. Do not exceed the maximum daily amount prescribed for your specific tablet strength, because both ingredients have dose limits and glipizide can cause low blood sugar if too much is taken.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Glipizide + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset or abdominal discomfort
• Gas or bloating
• Headache
• Dizziness
• Low blood sugar, which may be more likely if this tablet is stronger than your prior regimen or if meals are skipped

• Use caution if you have kidney disease, because metformin may not be appropriate or may need closer monitoring.
• Tell your doctor if you have liver disease, heart failure, or a history of alcohol misuse, as these can raise safety risks.
• Do not skip meals, especially after taking Glynase-MF Tablet, because glipizide can cause hypoglycemia.
• Be careful when driving or operating machinery until you know how this tablet affects your blood sugar and alertness.
• Tell your clinician if you are dehydrated, vomiting, having diarrhea, or planning surgery or imaging with contrast dye.
• Older adults may be more sensitive to low blood sugar and kidney-related effects.
• If your doctor changes you from lower-dose diabetes tablets to this Glynase-MF Tablet, watch closely for signs of low blood sugar during the transition.

• Alcohol
• Insulin and other diabetes medicines, which can increase hypoglycemia risk
• Cimetidine and certain kidney-affecting medicines that can raise metformin levels or side effects
• Steroids and some diuretics, which can raise blood sugar and reduce diabetes control
• Contrast dye used in some imaging tests, which may require temporary stopping of metformin

Store Glynase-MF Tablet in its original strip/box at room temperature, away from moisture and excess heat, and keep it out of reach of children.