Marcoprim DS 400 mg/80 mg Tablet

Marcoprim DS 400 mg/80 mg Tablet is a prescription antibiotic that combines sulfamethoxazole 400 mg and trimethoprim 80 mg in each tablet. It belongs to the sulfonamide/folate-antagonist antibiotic class and is used to treat certain bacterial infections. Doctors may prescribe Marcoprim DS 400 mg/80 mg Tablet for infections such as urinary tract infections, ear infections, bronchitis, and some skin infections when the bacteria are likely to respond to this combination.

How it works: The sulfamethoxazole and trimethoprim in Marcoprim DS 400 mg/80 mg Tablet work together to block two steps bacteria need to make folate, a nutrient they use to grow and multiply. By stopping bacterial growth at two points, this tablet helps the body clear the infection more effectively than either ingredient alone.

Marcoprim DS 400 mg/80 mg Tablet is the standard-strength double-strength tablet in this product line, with 400 mg sulfamethoxazole plus 80 mg trimethoprim in one tablet. It is often chosen when a doctor wants a tablet that provides a full treatment dose in a single unit, but it is not a starter or low-dose form and should be used only when this strength matches the prescribed regimen. Compared with lower strengths, this tablet may mean fewer tablets per dose, which can make dosing simpler for adults and older children when appropriate.

• Urinary tract infections
• Certain ear infections
• Bronchitis and other respiratory infections
• Some skin and soft tissue infections
• Traveler’s diarrhea in selected cases

• Swallow Marcoprim DS 400 mg/80 mg Tablet with a full glass of water.
• Take it exactly as prescribed, at evenly spaced times, and finish the full course even if you feel better.
• You may take this tablet with or without food; taking it with food can help reduce stomach upset.
• Drink plenty of fluids while using this antibiotic unless your doctor tells you to limit fluids.
• Do not crush or chew unless your pharmacist or prescriber specifically says it is okay.
• If a dose is missed, take it when remembered unless it is close to the next dose; do not double up.

Each Marcoprim DS 400 mg/80 mg Tablet provides 400 mg sulfamethoxazole and 80 mg trimethoprim. Depending on the infection, it may be taken once, twice, or in some cases three times daily, but the exact schedule and maximum daily dose are set by the doctor based on the condition being treated and the patient’s age and kidney function. Because this is the 400 mg/80 mg double-strength tablet, the prescribed amount should be followed carefully and not adjusted on your own.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sulfamethoxazole + Trimethoprim may include:

• Nausea
• Vomiting
• Loss of appetite
• Diarrhea
• Rash or itching
• Headache
• Mild sensitivity to sunlight

• Do not use if you have a known sulfonamide allergy or a serious allergy to trimethoprim-containing medicines.
• This tablet can be a higher-dose option for some regimens, so kidney problems, older age, or dehydration make close monitoring more important.
• Drink enough fluids to lower the risk of kidney-related side effects, unless your doctor tells you otherwise.
• Use caution if you have liver disease, kidney disease, folate deficiency, or a history of blood count problems.
• It can make your skin more sensitive to sunlight, so limit sun exposure and use protection outdoors.
• Tell your doctor if you take blood thinners or medicines that can raise potassium.
• Seek medical advice before driving if the medicine causes dizziness or blurred vision.

• Warfarin and other blood thinners
• ACE inhibitors or ARBs, which can increase potassium risk
• Spironolactone or other potassium-raising medicines
• Methotrexate, which can increase toxicity risk
• Phenytoin, which may interact with this antibiotic

Store Marcoprim DS 400 mg/80 mg Tablet in a dry place at room temperature, away from excess heat, moisture, and light, and keep it in the original strip/box until use.