Siaglide-M 50/500 Tablet PR

Siaglide-M 50/500 Tablet PR is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used to help lower blood sugar in adults with type 2 diabetes. Siaglide-M 50/500 Tablet PR is not for type 1 diabetes or diabetic ketoacidosis. It is usually used along with diet and exercise to improve blood sugar control.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar made by the liver by boosting natural gut hormone activity. Metformin reduces sugar production in the liver and helps the body use insulin better, and the tablet’s prolonged-release form is designed to release medicine gradually.

Siaglide-M 50/500 Tablet PR is the lower-strength sibling of Siaglide-M OD 100/1000 Tablet PR, so it may suit patients who need a gentler dose or whose doctor wants to build treatment step by step. Because it contains less sitagliptin and metformin per tablet, this strength may be chosen when a higher dose is not appropriate or not yet needed. It is still a prescription-strength tablet and should only be used exactly as directed.

• Type 2 diabetes blood sugar control
• Adjunct to diet and exercise
• May be used alone or with other diabetes medicines as prescribed
• Helps lower fasting and after-meal glucose

• Swallow the Siaglide-M 50/500 Tablet PR whole with water; do not crush, chew, or split it.
• Take it with food, usually with the evening meal if your prescriber tells you once-daily use, to reduce stomach upset.
• If your doctor prescribes it more than once daily, take it at evenly spaced times exactly as directed.
• Do not change to the higher-strength Siaglide-M OD 100/1000 Tablet PR unless your doctor tells you to.
• If you miss a dose, take it when remembered unless it is almost time for the next dose; do not double up.
• Keep taking it even if you feel well, because diabetes often has no symptoms.

Each Siaglide-M 50/500 Tablet PR contains sitagliptin 50 mg plus metformin 500 mg in prolonged-release form. The exact dosing schedule depends on your blood sugar goals, kidney function, and any other diabetes medicines you take; your doctor decides whether it is taken once daily or in another schedule. Do not exceed the daily amount prescribed, because higher total daily metformin or sitagliptin exposure can increase side effects and safety risks.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset or abdominal pain
• Gas or bloating
• Headache
• Upper respiratory symptoms
• Low appetite

• This is a stronger prescription tablet than starter-only metformin products, so do not use it unless a clinician has assessed your dose needs.
• Avoid heavy alcohol use, because it can increase the risk of metformin-related lactic acidosis.
• Use extra caution if you have kidney problems, because metformin dosing and safety depend on kidney function.
• Tell your doctor if you have liver disease, heart failure, or a history of pancreatitis.
• Low blood sugar can happen more often if Siaglide-M 50/500 Tablet PR is taken with insulin or a sulfonylurea.
• Do not drive or operate machinery if you feel dizzy or if your blood sugar is low.
• Tell your clinician if you are scheduled for contrast dye imaging or surgery, because temporary stopping may be needed.

• Insulin and sulfonylureas, which can raise the risk of low blood sugar
• Alcohol, which can increase safety risks with metformin
• Iodinated contrast dye used in some CT or angiogram procedures
• Certain medicines that affect kidney function or metformin clearance, including some diuretics and NSAIDs
• Other diabetes medicines that may need dose adjustment when combined

Store Siaglide-M 50/500 Tablet PR at room temperature in its original strip or box, away from moisture and excess heat.