Ignalis-M 50/500 Tablet ER

Ignalis-M 50/500 Tablet ER is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in one extended-release tablet. It belongs to the DPP-4 inhibitor and biguanide classes and is used to help lower blood sugar in adults with type 2 diabetes. This product is not for type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar made by the liver by supporting natural hormone signals. Metformin reduces sugar production in the liver and helps the body use insulin better, while the ER tablet releases metformin slowly over time.

Ignalis-M 50/500 Tablet ER contains sitagliptin 50 mg plus metformin 500 mg in each tablet, which is a mid-strength combination rather than a metformin-only or lower-dose sitagliptin option. The extended-release form is chosen when a doctor wants once-daily coverage with a lower metformin load per tablet and a steadier release through the day.

• Type 2 diabetes blood sugar control
• Used along with diet and exercise
• May be prescribed when one medicine is not enough
• Helps improve fasting and after-meal glucose
• Can support long-term A1C reduction

• Swallow Ignalis-M 50/500 Tablet ER whole with water; do not crush, split, or chew the extended-release tablet.
• Take it with a meal, usually once daily, unless your doctor gives different directions.
• Take it at the same time each day to help keep blood sugar control steady.
• Do not take extra tablets if you miss a dose; follow your prescriber’s instructions.
• If you notice the tablet shell in your stool, that can happen with some ER tablets and does not always mean the medicine did not work.

Each Ignalis-M 50/500 Tablet ER provides sitagliptin 50 mg and metformin 500 mg in an extended-release tablet. The usual dosing frequency for this type of product is once daily with food, but your doctor may adjust the schedule based on your blood sugar, kidney function, and other medicines. Do not exceed the amount your prescriber tells you to take, because the maximum daily dose depends on your full treatment plan and kidney status.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Diarrhea, especially from the metformin component
• Nausea or upset stomach
• Gas or bloating
• Headache
• Upper respiratory symptoms such as runny nose or sore throat
• Mild appetite change

• Ignalis-M 50/500 Tablet ER is for type 2 diabetes only and should not be used for diabetic ketoacidosis.
• Because this product contains metformin, kidney function must be checked before and during treatment.
• Avoid heavy alcohol use, which raises the risk of lactic acidosis with metformin-containing tablets.
• Tell your doctor if you have pancreatitis, heart failure, liver disease, or severe infection.
• Use caution when driving or operating machinery until you know how this medicine affects your blood sugar.
• If you take insulin or a sulfonylurea, your risk of low blood sugar may be higher.
• Do not crush or split the tablet, since that can change the extended-release effect.

• Insulin or sulfonylureas, such as glipizide or glimepiride, can increase the risk of hypoglycemia.
• Alcohol can raise the risk of metformin-related lactic acidosis.
• Iodinated contrast dye used for certain scans may require temporary stopping of metformin.
• Certain medicines that affect kidneys or blood sugar, including some diuretics and steroids, can change control.
• Digoxin levels may be affected in some patients taking sitagliptin-containing products.

Store Ignalis-M 50/500 Tablet ER in its original strip/box at room temperature, away from moisture and heat.