Glura M 500 Tablet

Glura M 500 Tablet is a prescription diabetes medicine that combines sitagliptin and metformin in one tablet. Each Glura M 500 Tablet contains sitagliptin and metformin as labelled, and it belongs to the DPP-4 inhibitor plus biguanide combination class. It is used together with diet and exercise to help improve blood sugar control in adults with type 2 diabetes. Lowering blood sugar can also help reduce the risk of diabetes-related complications over time.

How it works: Sitagliptin helps your body release more insulin after meals and lowers hormones that raise blood sugar. Metformin reduces sugar made by the liver and helps your body use insulin better, all in one tablet form.

Glura M 500 Tablet is a lower-strength tablet option within this combination, so it may suit adults who need less metformin and sitagliptin than higher-strength tablets provide. A doctor may choose Glura M 500 Tablet when starting combination therapy, when step-up treatment is needed, or when a smaller dose is better tolerated for the stomach and overall blood sugar plan. Because it is a tablet, it is taken by mouth and starts working from regular daily use rather than giving an immediate noticeable effect.

• Type 2 diabetes
• Blood sugar control along with diet and exercise
• Combination therapy when two medicines are needed
• May help lower fasting and after-meal glucose

• Swallow Glura M 500 Tablet whole with water; do not crush, chew, or split unless your prescriber tells you to.
• Take it with food if stomach upset occurs, since metformin can irritate the stomach in some people.
• Take it at the same time each day to keep blood sugar control steady.
• Follow the exact dosing schedule your doctor prescribes; do not take extra tablets if you miss a dose.
• If you are switching from another diabetes medicine, use the schedule your doctor gives you rather than changing on your own.

Each Glura M 500 Tablet provides sitagliptin plus metformin as labelled on the pack. The tablet may be taken once or twice daily depending on the prescribed plan, but the exact dose and timing are decided by the doctor based on your blood sugar, kidney function, and other medicines. Do not exceed the maximum daily amount your prescriber sets, because the right dose is individualized for this strength.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• nausea
• diarrhea
• stomach upset
• gas
• headache
• runny nose or upper respiratory symptoms
• low blood sugar is possible if used with insulin or a sulfonylurea

• Glura M 500 Tablet is for type 2 diabetes, not type 1 diabetes or diabetic ketoacidosis.
• Tell your doctor if you have kidney disease, because metformin-containing tablets may not be appropriate at certain kidney function levels.
• Use caution with alcohol, since heavy drinking raises the risk of lactic acidosis with metformin.
• If you take insulin or a sulfonylurea, your risk of low blood sugar can be higher.
• Tell your prescriber about heart failure, liver disease, or a history of pancreatitis before starting this tablet.
• Use caution when driving or operating machinery if you develop dizziness or low blood sugar symptoms.
• If you are having surgery or a contrast imaging procedure, your doctor may need to adjust this medicine temporarily.

• insulin
• sulfonylureas such as glipizide or glyburide
• alcohol
• iodinated contrast dye used for some CT scans or X-rays
• other medicines that can affect blood sugar, including corticosteroids or certain diuretics

Store Glura M 500 Tablet in its original strip or box at room temperature, away from moisture and heat.