Istamet 50 mg/1000 mg Tablet

Istamet 50 mg/1000 mg Tablet is a prescription diabetes medicine that combines sitagliptin 50 mg and metformin 1000 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used to help lower blood sugar in adults with type 2 diabetes. This strength is meant to be taken as part of a broader diabetes plan that includes diet and exercise. It is not used to treat type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps your body release more insulin only when blood sugar is high, which can help after meals. Metformin helps lower sugar made by the liver and improves how your body uses insulin, and together in this tablet they help control type 2 diabetes.

Istamet 50 mg/1000 mg Tablet is a higher metformin-strength combination than Istamet 50 mg/500 mg Tablet, so it may be chosen when a doctor wants the same sitagliptin dose with a stronger metformin amount in one tablet. Because of the 1000 mg metformin content, this tablet may be better suited for patients who already tolerate metformin and need a stronger tablet-based dose rather than a lower-strength option.

• Type 2 diabetes blood sugar control
• Added to diet and exercise
• May be used with other diabetes medicines
• Helps lower fasting and after-meal glucose
• Long-term glucose management

• Swallow the tablet whole with water; do not crush, chew, or split it unless your prescriber specifically tells you to.
• Take it with food if your stomach feels upset, since metformin can cause gastrointestinal side effects.
• Take it at the same time each day to help you remember doses.
• Follow the exact schedule your doctor prescribes; this tablet is not a one-size-fits-all dose.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Keep taking it even if you feel well, because type 2 diabetes often has no symptoms.

Each Istamet 50 mg/1000 mg Tablet provides 50 mg of sitagliptin and 1000 mg of metformin. Depending on your blood sugar response and kidney function, a doctor may prescribe it once or twice daily, but the exact schedule is individualized and not meant to be set on your own. Do not take more than your prescriber recommends; the total daily amount must stay within the limits chosen for you based on this strength and your other medicines.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset or abdominal discomfort
• Gas or bloating
• Headache
• Upper respiratory symptoms like a runny nose or sore throat
• Low blood sugar if used with insulin or a sulfonylurea

• This 50 mg/1000 mg strength has a higher metformin dose, so stomach side effects may be more noticeable than with lower-strength tablets in some people.
• Tell your doctor if you have kidney disease or are at risk for dehydration, because metformin may not be appropriate or may need closer monitoring.
• Avoid heavy alcohol use, which can raise the risk of lactic acidosis with metformin.
• Use caution if you have a history of pancreatitis or severe stomach pain.
• If you take insulin or a sulfonylurea, watch for low blood sugar and carry a fast sugar source with you.
• Tell your prescriber about heart disease, liver disease, or recent serious illness or surgery.
• Be careful when driving if you feel dizzy, weak, or have low blood sugar.

• Alcohol
• Iodinated contrast dye used for some CT scans or imaging tests
• Insulin or sulfonylureas such as glipizide or glimepiride
• Carbonic anhydrase inhibitors such as topiramate or acetazolamide
• Medicines that affect kidneys or dehydration risk, including some diuretics

Store Istamet 50 mg/1000 mg Tablet in its original strip/box at room temperature, away from moisture, heat, and direct light.