Alsita-M 100 Tablet ER

Alsita-M 100 Tablet ER is an oral diabetes medicine that combines sitagliptin and metformin in each tablet. Each Alsita-M 100 Tablet ER contains sitagliptin 100 mg plus metformin hydrochloride in an extended-release tablet, and it belongs to the DPP-4 inhibitor and biguanide classes. It is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes. This tablet is not for type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body raise insulin only when blood sugar is high and lowers the amount of sugar the liver makes after meals. Metformin lowers sugar production in the liver and helps the body use insulin better, and the tablet form provides convenient oral dosing for ongoing type 2 diabetes control.

Alsita-M 100 Tablet ER is the higher sitagliptin strength in this brand, paired with an extended-release metformin tablet for once-daily-style blood sugar support when a doctor wants a stronger sitagliptin dose. Because it is a higher-strength combination tablet, it is generally suited to people who have already been assessed for metformin and sitagliptin therapy and need a regimen that is not a starting dose for many patients. The extended-release tablet is designed to release metformin slowly, which may feel gentler on the stomach than immediate-release metformin for some people.

• Type 2 diabetes mellitus
• Blood sugar control with diet and exercise
• Combination therapy when one medicine is not enough
• Lowering fasting and after-meal glucose
• Long-term diabetes management

• Swallow Alsita-M 100 Tablet ER whole with water; do not crush, split, or chew the extended-release tablet.
• Take it with food or your largest meal if your prescriber advises, since metformin ER is often easier on the stomach when taken with food.
• Take it at the same time each day to help you remember doses and keep blood sugar steadier.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Check your blood sugar as directed, since the dose may be adjusted based on results and kidney function.

Each Alsita-M 100 Tablet ER provides sitagliptin 100 mg plus metformin hydrochloride in an extended-release tablet. The exact number of tablets taken per day depends on your doctor’s instructions and on your kidney function, current metformin dose, and prior diabetes treatment. Do not take more than prescribed, and do not use this higher-strength tablet as a substitute for a lower-strength product without medical guidance.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Diarrhea
• Nausea
• Stomach upset
• Gas or bloating
• Headache
• Upper respiratory symptoms such as a runny nose or sore throat
• Low blood sugar is more likely if it is taken with insulin or a sulfonylurea

• Do not use if you have type 1 diabetes or diabetic ketoacidosis.
• Because this is a higher-strength sitagliptin tablet, do not start, stop, or change the dose unless your prescriber tells you to.
• Metformin can increase the risk of lactic acidosis, especially if you have kidney disease, dehydration, liver disease, or heavy alcohol use.
• Tell your doctor if you have a history of pancreatitis, gallstones, heart failure, or serious kidney problems.
• Limit alcohol, since it can raise the risk of low blood sugar and lactic acidosis.
• Be careful driving or operating machinery if you feel dizzy or if your blood sugar is low.
• Tell your clinician about any planned contrast imaging tests, since metformin may need to be held temporarily.

• Insulin or sulfonylureas such as glipizide can increase the risk of low blood sugar.
• Alcohol can increase the risk of metformin-related lactic acidosis and low blood sugar.
• Iodinated contrast medicines used for some scans may require temporary interruption of metformin.
• Certain drugs that affect kidneys or dehydration risk, such as diuretics, can raise safety concerns.
• Some medicines may affect blood sugar control, so all prescriptions and supplements should be reviewed.

Store Alsita-M 100 Tablet ER at room temperature in its original strip/box, protected from moisture and heat.