Sitahenz M 50 mg/500 mg Tablet SR

Sitahenz M 50 mg/500 mg Tablet SR is an oral diabetes medicine that combines sitagliptin 50 mg and metformin 500 mg in each sustained-release tablet. It belongs to the DPP-4 inhibitor + biguanide combination class and is used to help improve blood sugar control in adults with type 2 diabetes. It is not insulin and is not used to treat type 1 diabetes or diabetic ketoacidosis. Sitahenz M 50 mg/500 mg Tablet SR is usually used along with diet and exercise.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar the liver makes by supporting natural incretin hormones. Metformin reduces sugar production in the liver and helps the body use insulin better, and the tablet form is designed to take these medicines by mouth over time.

The Sitahenz M 50 mg/500 mg Tablet SR strength gives a mid-range sitagliptin dose with a lower metformin amount per tablet, which can suit people who need combination treatment but may not tolerate a higher metformin load. Because this is a sustained-release tablet, it is meant to release medicine gradually, which may feel gentler on the stomach than an immediate-release tablet for some patients. A doctor may choose this strength when stepping up treatment or when matching the medicine to kidney function, blood sugar goals, and tolerability.

• Type 2 diabetes mellitus
• Improving blood sugar control along with diet and exercise
• Combination therapy when one medicine is not enough
• May be used when a doctor wants sitagliptin plus metformin in one SR tablet

• Swallow Sitahenz M 50 mg/500 mg Tablet SR whole with water; do not crush, split, or chew the sustained-release tablet.
• Take it with food, usually with the evening meal if your prescriber tells you to once daily, to reduce stomach upset.
• If your doctor prescribes it twice daily, take it exactly at the scheduled times and do not double up doses.
• Keep taking the tablet regularly even if you feel well, because high blood sugar often has no symptoms.
• Follow the meal plan, exercise plan, and blood sugar checks your clinician recommends while using Sitahenz M 50 mg/500 mg Tablet SR.

Each Sitahenz M 50 mg/500 mg Tablet SR contains sitagliptin 50 mg and metformin 500 mg. The dose may be taken once daily or twice daily depending on the prescriber’s plan, and the exact maximum daily amount should be set by your doctor based on your kidney function and prior diabetes medicines. Do not change the schedule or take extra tablets on your own.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea
• Diarrhea
• Stomach upset or abdominal discomfort
• Gas or bloating
• Headache
• Upper respiratory symptoms such as a runny nose or sore throat
• Mild dizziness or tiredness

• Do not use Sitahenz M 50 mg/500 mg Tablet SR for type 1 diabetes or diabetic ketoacidosis.
• Tell your doctor if you have kidney disease, because metformin-containing tablets may need dose adjustment or may not be appropriate.
• Avoid heavy alcohol use, since alcohol can raise the risk of lactic acidosis with metformin.
• Use caution if you have a history of pancreatitis, heart failure, or serious liver disease.
• Watch for low blood sugar if Sitahenz M 50 mg/500 mg Tablet SR is combined with insulin or other diabetes medicines that can cause hypoglycemia.
• Do not take extra tablets to make up for a missed dose; doubling up can increase side effects.
• If you need an imaging test with iodinated contrast, tell your healthcare team you take metformin-containing medicine.

• Insulin or sulfonylureas, which can increase the risk of low blood sugar
• Alcohol, which can increase the risk of lactic acidosis and stomach side effects
• Iodinated contrast dye used for some CT scans or procedures
• Medicines that affect kidney function or can raise metformin levels, such as certain diuretics or cimetidine
• Rifampin or other medicines that may alter sitagliptin/metformin handling in the body

Store Sitahenz M 50 mg/500 mg Tablet SR at room temperature in a dry place, away from excess heat and moisture, and keep it in the original strip until use.