Sitara-M 100/500 Tablet ER

Sitara-M 100/500 Tablet ER is a prescription diabetes medicine that contains sitagliptin 100 mg and metformin 500 mg in each extended-release tablet. It belongs to the DPP-4 inhibitor and biguanide classes and is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes. This tablet is not for type 1 diabetes or diabetic ketoacidosis. Because it is an extended-release tablet, it is designed to release medicine slowly over time.

How it works: Sitagliptin helps your body release more insulin after meals and lowers the amount of sugar made by the liver by increasing natural gut hormones. Metformin reduces sugar production in the liver and helps your body use insulin better, and the tablet form provides a steady release as it passes through the day.

Sitara-M 100/500 Tablet ER is the higher sitagliptin strength in this brand family, and it delivers the full 100 mg sitagliptin dose plus 500 mg metformin in one tablet. It may be chosen for people whose doctor wants the standard sitagliptin amount with a lower metformin amount, or for those switching from the 50/500 Tablet ER based on glucose control and tolerance. This strength is not a casual starting choice for everyone and should be used only when a clinician has already assessed the patient.

• Type 2 diabetes
• Improving blood sugar control
• Add-on therapy with diet and exercise
• May be used alone or with other diabetes medicines
• Long-term glucose management

• Take Sitara-M 100/500 Tablet ER by mouth with a glass of water.
• Swallow the tablet whole; do not crush, chew, or split it because it is extended-release.
• Take it with food, usually once daily, unless your doctor tells you differently.
• Take it at the same time each day to help you remember and keep levels steady.
• If you miss a dose, take it when you remember unless it is close to the next dose; do not double up.
• Follow your doctor’s meal plan, exercise plan, and blood sugar checks while using this tablet.

Each Sitara-M 100/500 Tablet ER provides sitagliptin 100 mg and metformin 500 mg. It is commonly taken once daily, and the exact dose, timing, and whether it should be combined with other diabetes medicines are decided by the prescriber. Do not take more than the amount your doctor prescribes, because metformin-containing products have limits based on safety and kidney function.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Diarrhea
• Nausea
• Stomach upset or abdominal pain
• Gas or bloating
• Headache
• Upper respiratory symptoms
• Dizziness, especially if blood sugar drops or if you are dehydrated

• This is a higher-strength Sitara-M tablet, so it should be used only under medical supervision.
• Do not use it for type 1 diabetes or diabetic ketoacidosis.
• Tell your doctor if you have kidney disease, because metformin dosing and use depend on kidney function.
• Limit alcohol, since heavy drinking raises the risk of lactic acidosis with metformin.
• Use caution if you have a history of pancreatitis.
• Be careful with driving or operating machinery if you feel dizzy or if your blood sugar is low.
• Tell your doctor if you are dehydrated, fasting, sick with vomiting/diarrhea, or scheduled for contrast imaging.

• Insulin and sulfonylureas, which can increase the risk of low blood sugar
• Alcohol, which can raise the risk of lactic acidosis
• Contrast dye used for certain imaging studies, which may affect kidney function and metformin safety
• Other medicines that affect kidney function, including some diuretics and NSAIDs
• Strong enzyme/transport interactions are less of a concern than kidney-related interactions, but all medicines should be reviewed

Store Sitara-M 100/500 Tablet ER at room temperature in its original strip or box, away from excess heat, moisture, and children.