Manocol 400 Tablet DR

Manocol 400 Tablet DR is a delayed-release mesalamine tablet that contains mesalazine 400 mg in each tablet. It belongs to the aminosalicylate class and is used to help treat and maintain remission in ulcerative colitis and other inflammatory bowel conditions as directed by a doctor. Because it is a delayed-release tablet, Manocol 400 Tablet DR is designed to pass through the stomach and release medicine later in the intestine. This helps reduce inflammation where it is needed most.

How it works: Mesalamine works by lowering inflammation in the lining of the intestines, which can help reduce diarrhea, blood in the stool, and abdominal pain from inflammatory bowel disease. As a delayed-release tablet, Manocol 400 Tablet DR is built to release the medicine after swallowing so more of the dose reaches the intestines.

Manocol 400 Tablet DR is a lower-strength tablet compared with larger mesalamine tablets, so it can be useful when a prescriber wants smaller dose steps or easier dose adjustment. The delayed-release form may also be chosen to target release in the bowel rather than in the stomach, which can help some patients tolerate treatment better. A doctor may select this strength when starting, adjusting, or fine-tuning mesalamine therapy.

• Ulcerative colitis treatment
• Maintenance of ulcerative colitis remission
• Inflammatory bowel disease symptom control as prescribed
• Reduction of bowel inflammation
• Doctor-directed intestinal anti-inflammatory therapy

• Swallow Manocol 400 Tablet DR whole with water; do not crush, chew, or split it unless your prescriber specifically says otherwise.
• Take it exactly at the times your doctor prescribed, even if you feel better.
• You can usually take it with or without food, but taking it the same way each day may help you remember.
• Drink enough fluids while using this medicine unless your doctor has told you to restrict fluids.
• Do not use the tablet to treat sudden severe abdominal pain, fever, or a flare without contacting your doctor.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.

Each Manocol 400 Tablet DR provides mesalamine 400 mg per tablet. The total daily dose may be taken once daily or in divided doses depending on the condition being treated and the prescriber’s plan; the maximum dose depends on the individual regimen and should be set by the doctor. Because this is a prescription delayed-release strength, your doctor decides whether 400 mg tablets alone are enough or whether they should be combined with other strengths to reach the right daily dose.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Mesalazine / Mesalamine may include:

• Headache
• Nausea
• Abdominal pain or cramping
• Diarrhea
• Gas or bloating
• Vomiting
• Mild rash

• Use caution if you have kidney disease, because mesalamine can affect kidney function and monitoring may be needed.
• Tell your doctor about any history of liver disease, since this medicine may require closer follow-up.
• Report aspirin or salicylate sensitivity before taking Manocol 400 Tablet DR.
• Do not crush or chew the delayed-release tablet, because that can change how and where the medicine is released.
• Alcohol can irritate the stomach and bowel, so ask your doctor whether it is safe for you.
• Tell your prescriber if you are pregnant, trying to become pregnant, or breastfeeding.
• Use care when driving or doing tasks if you feel dizzy, weak, or unwell after a dose.

• Azathioprine
• 6-mercaptopurine
• Warfarin and other blood thinners
• Other medicines that can affect the kidneys, including NSAIDs such as ibuprofen or naproxen
• Other salicylates or mesalamine products

Store Manocol 400 Tablet DR at room temperature in the original strip/box, protected from moisture and heat, and keep it out of reach of children.