Mesacol 4 g Enema

Mesacol 4 g Enema is a rectal mesalazine (mesalamine) medicine used to treat inflammation in the lower part of the colon and rectum. Each bottle contains 4 g of mesalazine, a 5-aminosalicylic acid (5-ASA) anti-inflammatory drug. It is commonly prescribed for ulcerative colitis, especially when symptoms are limited to the rectum or left side of the colon. Mesacol 4 g Enema helps reduce inflammation, which can lessen bleeding, urgency, and diarrhea.

How it works: Mesalazine works by calming inflammation in the lining of the colon and rectum, which helps the bowel heal. With Mesacol 4 g Enema, the medicine is delivered directly to the inflamed area for targeted relief.

Mesacol 4 g Enema is a higher-strength, doctor-directed rectal mesalazine option, not a starting strength for everyone. Because it delivers 4 g directly to the lower bowel, a clinician may choose it when a smaller dose is not enough or when more intensive local treatment is needed for active inflammation. It is different from oral mesalamine tablets because it works mainly where it is placed rather than throughout the whole digestive tract.

• Ulcerative colitis flare treatment
• Inflammation of the rectum
• Inflammation of the left colon
• Reducing rectal bleeding
• Reducing urgency and diarrhea

• Use Mesacol 4 g Enema exactly as prescribed; this is a rectal medicine, not an oral tablet.
• Try to use it at bedtime when possible so the medicine can stay in the bowel longer.
• Empty your bowels before using the enema if your doctor or pharmacist has instructed you to do so.
• Lie on your left side and insert the bottle nozzle carefully as directed in the package instructions.
• Administer the full 4 g bottle unless your prescriber tells you otherwise.
• Wash your hands before and after use; do not swallow the enema.

Each Mesacol 4 g Enema bottle provides 4 g of mesalazine for one rectal dose. Depending on your condition, it may be used once daily or as otherwise directed by your doctor, and the exact schedule can vary with symptom severity and treatment goals. Do not use more than prescribed; your doctor decides whether this 4 g strength is appropriate and how long you should continue it.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Mesalazine / Mesalamine may include:

• Rectal discomfort or irritation
• Abdominal pain or cramping
• Gas or bloating
• Headache
• Nausea
• Loose stools
• Leakage or urgency after dosing

• Use only if your doctor has confirmed this rectal strength is appropriate for your ulcerative colitis treatment.
• Tell your prescriber if you have kidney disease, a history of kidney stones, or are at risk for dehydration.
• Use caution if you have liver disease or a prior allergy to mesalazine, mesalamine, sulfasalazine, or salicylates.
• This medicine is for rectal use only and should not be taken by mouth.
• If symptoms worsen, fever develops, or bleeding becomes heavy, contact your doctor promptly.
• Tell your healthcare professional about all medicines you take, especially other 5-ASA products or drugs that can affect kidney function.

• Other mesalazine or mesalamine products
• Aminosalicylates such as sulfasalazine
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen
• Medicines that can affect kidney function, including some diuretics or immunosuppressants
• Azathioprine or 6-mercaptopurine

Store Mesacol 4 g Enema at room temperature in the original pack, away from excess heat and moisture, and keep it out of reach of children.