Mesacol 400 mg Tablet

Mesacol 400 mg Tablet is an oral medicine that contains 400 mg of mesalazine (mesalamine) in each tablet. It belongs to the aminosalicylate class and is used to treat inflammatory bowel disease, especially ulcerative colitis, by helping reduce inflammation in the intestines. Mesacol 400 mg Tablet is manufactured by Sun Pharmaceutical Industries Ltd. and comes in a strip/box of 10 tablets. It is taken by mouth and is used for bowel inflammation control, not for quick relief of sudden severe symptoms.

How it works: Mesalazine works inside the bowel lining to reduce chemicals that cause swelling, pain, and irritation. In tablet form, Mesacol 400 mg Tablet delivers the medicine orally so it can act where inflammation is present in the intestines.

Mesacol 400 mg Tablet is a standard, lower-per-tablet strength compared with Mesacol 800 mg Tablet, which can be useful when a doctor wants more flexible dose adjustment. The 400 mg tablet may suit people who need smaller divided doses or gradual dose titration based on their condition and response. Doctors choose the strength based on the total daily dose needed, how well the person tolerates mesalamine, and the treatment goal.

• Ulcerative colitis
• Maintenance of remission in inflammatory bowel disease
• Reduction of bowel inflammation
• Symptom control in colonic inflammation

• Swallow Mesacol 400 mg Tablet whole with water unless your doctor tells you otherwise.
• Take it exactly as prescribed; do not crush or chew the tablet if your doctor has not approved it.
• Try to take it at the same times each day to keep a steady effect.
• It may be taken with or without food unless your prescriber advises otherwise.
• Drink enough water while using this medicine, especially if you have diarrhea.
• Do not change to Mesacol 800 mg Tablet or any other mesalamine strength without medical advice.

Each Mesacol 400 mg Tablet provides 400 mg of mesalazine. The number of tablets and how often you take them depends on the condition being treated, your symptoms, and your doctor’s prescription; some people need multiple daily doses, while others may use a higher total daily amount in divided doses. Do not exceed the maximum daily dose set by your doctor, and do not adjust the dose on your own.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Mesalazine / Mesalamine may include:

• Headache
• Nausea
• Abdominal pain
• Diarrhea
• Gas or bloating
• Vomiting
• Mild rash

• Tell your doctor if you have kidney disease, liver disease, or a history of kidney stones before taking Mesacol 400 mg Tablet.
• Use caution if you have had an allergic reaction to mesalamine, salicylates, or sulfasalazine.
• Report new or worsening stomach pain, bloody stools, or fever, since these may mean your colitis is getting worse.
• Stay hydrated because diarrhea can increase the risk of dehydration and kidney problems.
• Tell your doctor about all medicines you take, especially drugs that can affect the kidneys.
• Avoid driving or activities that require alertness if you feel dizzy, weak, or unwell after taking it.
• If you are pregnant or breastfeeding, use this medicine only if your doctor says it is appropriate.

• Azathioprine or 6-mercaptopurine
• Other medicines that can affect the kidneys, including some NSAIDs
• Warfarin and other blood thinners
• Other mesalamine or aminosalicylate products

Store Mesacol 400 mg Tablet in its original strip at room temperature, away from moisture, heat, and direct light.