Combitide 125 Inhaler

Combitide 125 Inhaler is a combination inhaled medicine containing salmeterol and fluticasone propionate in the labeled 125 strength per inhaler dose. It belongs to the long-acting beta2-agonist plus inhaled corticosteroid class and is used to help control asthma symptoms and reduce flare-ups. Because it is an inhaler, it delivers medicine directly to the lungs for regular maintenance treatment rather than quick relief of sudden breathing problems. Combitide 125 Inhaler is manufactured by Sun Pharmaceutical Industries Ltd. and is supplied in a strip/box of 10 inhalers.

How it works: Salmeterol relaxes the muscles around the airways so they stay open longer and breathing is easier over time. Fluticasone propionate reduces inflammation and swelling in the lungs, and the inhaler form sends both medicines straight into the airways for maintenance control.

Combitide 125 Inhaler is the 125-strength inhaler in this product line, so it is generally suited to patients whose doctor has decided that this maintenance strength fits their asthma control needs. In practice, a clinician may choose Combitide 125 Inhaler when a lower-strength or different form is not appropriate, or when symptom control needs to be balanced with inhaled steroid exposure. It should be used exactly as prescribed, because the right inhaler strength depends on the individual and how well asthma is controlled.

• Asthma maintenance treatment
• Reducing day-to-day wheezing
• Helping prevent asthma flare-ups
• Long-term control of airway inflammation
• Improving breathing symptoms when used regularly

• Use Combitide 125 Inhaler exactly the way your doctor or pharmacist shows you; this is a maintenance inhaler, not a rescue inhaler for sudden attacks.
• Take it at the same times each day if you are prescribed regular daily use.
• Do not use extra puffs to treat sudden shortness of breath; use your prescribed quick-relief inhaler and seek help if symptoms worsen.
• After each use, rinse your mouth with water and spit it out to lower the risk of oral thrush.
• Prime, shake, and inhale the medicine only as instructed for your specific inhaler device.
• Do not stop using Combitide 125 Inhaler suddenly unless your prescriber tells you to.

Combitide 125 Inhaler delivers the labeled 125 dose of salmeterol plus fluticasone propionate in each inhaled dose from this product. The exact number of inhalations, how often to use it, and the maximum daily amount must be set by the doctor based on asthma severity and response, and this medicine is not for fast relief of an acute asthma attack.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Salmeterol + Fluticasone Propionate may include:

• Throat irritation
• Hoarseness
• Oral thrush (yeast infection in the mouth)
• Headache
• Cough after inhalation
• Tremor or shakiness
• Palpitations or a faster heartbeat

• Not for sudden asthma attacks; keep a rescue inhaler available.
• Use caution if you have heart disease, high blood pressure, arrhythmias, hyperthyroidism, seizures, or diabetes.
• Rinse and spit after each use to reduce fungal infection in the mouth.
• Tell your doctor if you have been using oral steroids, because steroid dose changes may need monitoring.
• Use caution if you have a history of cataracts, glaucoma, or bone loss with inhaled steroids.
• Do not use more often than prescribed, because higher beta-agonist exposure can increase tremor, heart racing, and low potassium risk.
• If your breathing gets worse after a dose, get urgent medical advice.

• Other long-acting beta-agonists or asthma combination inhalers containing a LABA
• Strong CYP3A4 inhibitors such as ritonavir, ketoconazole, or clarithromycin
• Beta-blockers, including some eye drops used for glaucoma
• Monoamine oxidase inhibitors and tricyclic antidepressants
• Diuretics that can lower potassium

Store Combitide 125 Inhaler at room temperature in a dry place, away from heat, moisture, and direct sunlight, and keep the inhaler capped or closed as directed by the device instructions.