Refsav 100 Tablet

Refsav 100 Tablet is an oral tablet that contains sacubitril and valsartan, with 100 mg sacubitril/103 mg valsartan in each tablet. It belongs to a class of medicines used for heart failure and blood pressure management. Refsav 100 Tablet is prescribed to help reduce the strain on the heart and lower the risk of worsening heart failure in suitable patients. Your doctor may also use it when blood pressure control needs a medicine in this class.

How it works: As a tablet, Refsav 100 Tablet releases sacubitril and valsartan after you swallow it with water. Sacubitril helps the body get rid of extra salt and water, while valsartan relaxes blood vessels, so the heart can pump with less effort.

Refsav 100 Tablet is a mid-strength tablet in the sacubitril/valsartan range, sitting between Refsav 50 Tablet and Refsav 200 Tablet. It is not the usual starting strength for everyone; doctors often choose Refsav 100 Tablet after assessing tolerance, kidney function, blood pressure, and response to a lower dose or when a patient needs an appropriate step-up from Refsav 50 Tablet.

• Heart failure treatment
• Helps lower risk of heart failure hospitalisation
• Blood pressure management when prescribed
• Reduces strain on the heart
• Supportive long-term heart medicine

• Swallow Refsav 100 Tablet whole with water; do not crush, chew, or split it unless your doctor tells you to.
• Take it at the same time each day to help you remember your doses.
• It may be taken with or without food.
• If it upsets your stomach or makes you feel lightheaded, ask your prescriber or pharmacist how to time it safely.
• Do not take extra tablets to make up for a missed dose without medical advice.
• Because this is a standard tablet, there is no flavouring or chewing requirement.

Each Refsav 100 Tablet provides 100 mg sacubitril plus 103 mg valsartan per tablet. How often you take it depends on your diagnosis, blood pressure, kidney function, and how you respond; many patients take it twice daily, but your doctor must decide the exact schedule and whether this strength is appropriate. Do not increase the dose on your own, and do not exceed the amount your prescriber specifies.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sacubitril + Valsartan may include:

• Dizziness or lightheadedness, especially after the first doses
• Low blood pressure
• Tiredness
• Cough
• Nausea
• Raised potassium levels
• Kidney function changes

• Tell your doctor if you have ever had angioedema with any ACE inhibitor or ARB; this medicine can cause serious swelling in some people.
• Refsav 100 Tablet can lower blood pressure, so standing up quickly may cause dizziness or fainting.
• Avoid potassium supplements or salt substitutes unless your clinician says they are safe, because this strength can raise potassium.
• Alcohol may increase dizziness and make low blood pressure worse.
• Do not use during pregnancy; the valsartan part can harm an unborn baby.
• Tell your doctor about kidney disease, liver disease, dehydration, or a recent diuretic dose change before starting this tablet.
• Use caution when driving or operating machinery until you know how Refsav 100 Tablet affects you.

• ACE inhibitors such as lisinopril or enalapril
• Aliskiren, especially in people with diabetes
• Potassium supplements or potassium-sparing diuretics like spironolactone
• NSAIDs such as ibuprofen or naproxen
• Lithium

Store Refsav 100 Tablet in its original strip or box at room temperature, away from moisture, heat, and out of reach of children.