Azmarda 200 mg Tablet

Azmarda 200 mg Tablet is a prescription medicine that contains sacubitril 97 mg plus valsartan 103 mg in each tablet, for a total strength of 200 mg. It belongs to a heart-failure medicine class called ARNI, which combines a neprilysin inhibitor with an angiotensin receptor blocker. Azmarda 200 mg Tablet is used to help treat chronic heart failure and reduce the risk of hospitalization in appropriate patients. It may also be used in certain adults with reduced heart function when prescribed by a doctor.

How it works: Sacubitril helps your body keep more of its natural helpful peptides, which can relax blood vessels and lower strain on the heart. Valsartan blocks a hormone signal that tightens blood vessels and raises blood pressure, and this tablet combines both actions in one oral dose.

Azmarda 200 mg Tablet is a higher-strength option compared with Azmarda 50 mg Tablet and Azmarda 100 mg Tablet, so it is usually chosen for patients whose doctor has already assessed their response and tolerance to lower strengths. Because this tablet delivers a full 200 mg dose, it is not a starter strength for most people and may be more suitable once a patient has been titrated upward. The exact strength and schedule should be individualized by the prescriber based on blood pressure, kidney function, and how well the earlier doses were tolerated.

• Chronic heart failure treatment
• Reduced ejection fraction heart failure
• Helps lower risk of heart-failure hospitalization
• Improves blood vessel relaxation and blood flow
• Blood pressure control in selected patients under specialist care

• Swallow Azmarda 200 mg Tablet whole with water; do not crush or chew unless your pharmacist or doctor specifically tells you to.
• Take it at the same time each day to help keep an even level in your body.
• You may take it with or without food unless your prescriber gives different instructions.
• If you feel dizzy when standing, rise slowly from sitting or lying positions.
• Do not change the dose on your own, especially because this is the 200 mg strength.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.

Each Azmarda 200 mg Tablet provides sacubitril 97 mg and valsartan 103 mg, which is a full higher-strength tablet. Depending on your condition and tolerance, a doctor may prescribe it once daily or more commonly twice daily for heart failure management, but the exact schedule must be set by the prescriber. The maximum daily amount and whether this strength is appropriate for you depend on your blood pressure, kidney function, and other medicines.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sacubitril + Valsartan may include:

• Dizziness, which may be more noticeable with the 200 mg strength
• Low blood pressure or lightheadedness
• Cough
• Tiredness
• High potassium level
• Kidney function changes
• Diarrhea or nausea

• This is a higher-strength tablet, so it should be used only if your doctor has decided the lower strengths were not enough or were already tolerated.
• Do not use if you are pregnant; sacubitril and valsartan can seriously harm an unborn baby.
• Do not take with an ACE inhibitor, and allow the required washout period if switching from one.
• Use caution if you have low blood pressure, dehydration, kidney disease, or liver disease.
• Avoid potassium supplements or salt substitutes with potassium unless your doctor approves them.
• Be careful with driving or standing quickly if the tablet makes you dizzy.
• Tell your prescriber about a history of angioedema or swelling with blood pressure medicines.

• ACE inhibitors such as lisinopril or enalapril
• Aliskiren, especially in people with diabetes
• Potassium supplements or potassium-sparing diuretics such as spironolactone
• NSAIDs such as ibuprofen or naproxen, which can affect kidneys and blood pressure
• Lithium, because levels may rise

Store Azmarda 200 mg Tablet in its original strip or box at room temperature, away from moisture and excess heat.