Syncapone 100 Tablet

Syncapone 100 Tablet is a prescription anti-Parkinson medicine that contains levodopa, carbidopa, and entacapone in each tablet at the strength labeled as Syncapone 100. This triple-combination tablet is used to help improve movement symptoms of Parkinson’s disease such as stiffness, slowness, tremor, and “wearing-off” between doses. Levodopa helps replace the brain chemical dopamine, carbidopa helps more levodopa reach the brain, and entacapone helps levodopa last longer. It is manufactured by Sun Pharmaceutical Industries Ltd. and supplied as a strip/box of 10 tablets.

How it works: In this tablet, levodopa is changed into dopamine in the brain, which helps improve movement. Carbidopa reduces levodopa breakdown before it reaches the brain, and entacapone slows levodopa breakdown so the dose can work longer.

Syncapone 100 Tablet is a mid-strength tablet in this brand line, sitting between Syncapone 50 Tablet and Syncapone 150 Tablet. It may suit patients who need more symptom control than the 50-strength but are not yet ready for the higher 150-strength tablet. Doctors may choose Syncapone 100 Tablet to fine-tune response, reduce off-time, and balance benefit with side effects.

• Parkinson’s disease symptom control
• Reduction of “wearing-off” periods
• Stiffness and slowness of movement
• Tremor related to Parkinson’s disease
• Adjunct treatment when levodopa alone is not enough

• Swallow Syncapone 100 Tablet whole with water; do not crush or chew unless your doctor specifically tells you to.
• Take it exactly at the times prescribed, because timing matters for Parkinson’s symptom control.
• If it upsets your stomach, it may be taken with a light snack, but high-protein meals can reduce levodopa absorption in some people.
• Avoid suddenly changing the number of tablets or the dosing schedule on your own.
• If your doctor advises multiple daily doses, keep the spacing consistent each day.
• If a dose is missed, follow your prescriber’s instructions; do not double up unless told to do so.

Each Syncapone 100 Tablet provides the labeled strength of levodopa, carbidopa, and entacapone in one tablet, and it is a higher-strength Parkinson tablet that should be used only when a clinician has assessed the need for it. The exact number of tablets per day and the dosing frequency depend on your prior levodopa response, and the maximum daily amount is individualized by the prescriber based on symptom control and tolerability. Do not use this tablet as a self-started dose or change the total daily dose without medical advice.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Levodopa + Carbidopa + Entacapone may include:

• Nausea
• Dizziness or lightheadedness
• Diarrhea
• Abdominal discomfort
• Sleepiness or sudden drowsiness
• Dark urine or sweat due to entacapone
• More noticeable side effects if the dose is too strong for you

• Syncapone 100 Tablet is a higher-strength Parkinson tablet, so it may be more likely to cause nausea, dizziness, or involuntary movements if the dose is too high for you.
• Be careful when standing up quickly, especially when starting or changing the dose, because blood pressure can drop.
• Do not drive or operate machinery until you know how this tablet affects your alertness and movements.
• Tell your doctor if you have a history of heart disease, arrhythmia, liver disease, glaucoma, ulcers, or psychiatric illness.
• Limit alcohol unless your doctor says it is safe, since alcohol can worsen dizziness and sleepiness.
• Do not stop Parkinson medicines suddenly unless instructed; abrupt changes can worsen symptoms.
• Let your clinician know if you become confused, see things that are not there, or develop unusual urges or excessive movements.

• MAO inhibitors or recent MAOI use
• Iron supplements or multivitamins containing iron, which can reduce levodopa absorption
• Nonselective beta blockers or blood pressure medicines that may increase dizziness
• Antipsychotic medicines that can counteract levodopa effects
• High-protein meals that may make levodopa work less well in some patients

Store Syncapone 100 Tablet in its original strip/box at room temperature, away from moisture, heat, and direct light.