Syncapone 150 Tablet (37.5 + 150 + 200 mg)

Syncapone 150 Tablet is a prescription anti-Parkinsonian medicine that combines levodopa, carbidopa, and entacapone in each tablet. It is used to help manage symptoms of Parkinson’s disease such as stiffness, slowness, tremor, and movement “wearing off” during the day. The tablet form is intended for oral use and is manufactured by Sun Pharmaceutical Industries Ltd. This is the Syncapone 150 Tablet strength, so it contains the labeled higher-strength combination of these three medicines in one tablet.

How it works: Levodopa turns into dopamine in the brain, helping improve movement in Parkinson’s disease, while carbidopa helps more levodopa reach the brain and lowers nausea. Entacapone blocks an enzyme that breaks down levodopa too quickly, so the effect of each Syncapone 150 Tablet can last longer.

Syncapone 150 Tablet is a higher-strength option compared with Syncapone 50 Tablet and Syncapone 100 Tablet, so it is generally chosen for people whose symptoms are not controlled well enough with lower strengths or who have already been stabilized on levodopa/carbidopa/entacapone therapy. Because it delivers a stronger dose in each tablet, a doctor may use it to reduce the number of tablets needed while still matching the patient’s prescribed levodopa dose.

• Parkinson’s disease symptom control
• Reducing end-of-dose “wearing off”
• Improving stiffness and slowness
• Helping control tremor and movement problems

• Take Syncapone 150 Tablet by mouth with water exactly as prescribed by your doctor.
• Swallow the tablet whole; do not crush or chew it unless your prescriber tells you otherwise.
• Take it at the same times each day to keep symptoms more steady.
• If it upsets your stomach, it may be taken with food, but very high-protein meals can reduce levodopa absorption.
• Avoid suddenly stopping Syncapone 150 Tablet without medical advice, because Parkinson’s symptoms can worsen.
• If you miss a dose, follow your doctor’s instructions or the medication label; do not double up unless told to do so.

Each Syncapone 150 Tablet contains the labeled 150-strength combination of levodopa, carbidopa, and entacapone per tablet. The exact number of tablets per day, dosing interval, and maximum daily dose are individualized by the prescriber based on symptom control, other Parkinson’s medicines, and how well you tolerate this higher-strength tablet.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Levodopa + Carbidopa + Entacapone may include:

• Nausea or vomiting
• Dizziness or lightheadedness
• Sleepiness or sudden drowsiness
• Diarrhea
• Darkened urine, sweat, or saliva
• Dry mouth
• More noticeable involuntary movements (dyskinesia), which can be more likely as the dose increases

• Syncapone 150 Tablet is a higher-strength tablet and should only be used when a doctor has assessed the dose carefully.
• It can cause dizziness or sleepiness, so be careful driving, operating machinery, or standing up quickly.
• Alcohol may worsen drowsiness, dizziness, or poor balance.
• Tell your doctor if you have heart disease, liver disease, kidney problems, glaucoma, a history of ulcers, or mental health conditions.
• This medicine may lower blood pressure, especially when rising from sitting or lying down.
• Do not use it with nonselective MAO inhibitors or within 14 days of stopping one.
• Tell your clinician if you have a history of melanoma or unusual skin changes, because levodopa therapy needs medical review.

• MAO inhibitors, especially nonselective MAOIs
• Antipsychotics and certain anti-nausea medicines that block dopamine
• Iron supplements, which can reduce absorption
• Blood pressure medicines, which may add to dizziness or low blood pressure
• High-protein meals, which can reduce levodopa effect

Store Syncapone 150 Tablet at room temperature in its original strip/box, away from moisture, heat, and light, and keep it out of reach of children.