Syncapone 50 Tablet (12.5 + 50 + 200 mg)

Syncapone 50 Tablet is an anti-Parkinson medicine that contains levodopa, carbidopa, and entacapone in each tablet, as labelled. It is used to help manage symptoms of Parkinson’s disease such as stiffness, slowness, and tremor, especially when levodopa alone is not enough or wears off before the next dose. The combination in Syncapone 50 Tablet helps the body use levodopa more effectively and for longer. It is supplied as a tablet from Sun Pharmaceutical Industries Ltd. in packs of 10 tablets.

How it works: Syncapone 50 Tablet combines three medicines in one tablet: levodopa replaces the dopamine the brain is missing, carbidopa helps more levodopa reach the brain, and entacapone slows levodopa breakdown so it lasts longer. Together, this tablet helps improve movement symptoms and can reduce end-of-dose “off” periods in Parkinson’s disease.

Syncapone 50 Tablet is the lower-strength tablet in this brand line, with a smaller levodopa dose per tablet than Syncapone 100 Tablet and Syncapone 150 Tablet. That can make it a better choice for people who need a more gradual adjustment, have more sensitivity to levodopa-related side effects, or need a dose that is easier for the prescriber to fine-tune. Your doctor may choose Syncapone 50 Tablet when they want to reduce “wearing off” while keeping the dose lower than the stronger tablet options.

• Parkinson’s disease
• Stiffness and slowed movement
• Tremor control
• “Wearing off” between levodopa doses
• Motor fluctuations in Parkinson’s disease

• Swallow Syncapone 50 Tablet whole with water unless your doctor tells you otherwise.
• Take it exactly at the times prescribed; timing matters for Parkinson’s symptom control.
• If it upsets your stomach, it may be taken with food, but high-protein meals can delay or reduce levodopa absorption.
• Do not crush or chew the tablet unless your clinician specifically instructs you to.
• Avoid suddenly stopping Syncapone 50 Tablet; doses usually need to be changed gradually by a doctor.
• If you miss a dose, take it when you remember unless it is close to the next dose; do not double up.

Each Syncapone 50 Tablet contains the labeled dose of levodopa, carbidopa, and entacapone in one tablet, with the levodopa amount lower than the 100 mg and 150 mg strengths. It is usually taken several times a day, with the exact schedule and maximum daily dose set by the prescriber based on symptom control, response, and tolerance. Because this is a prescription Parkinson’s medicine, the doctor decides whether Syncapone 50 Tablet is the right strength and how many tablets per day are appropriate.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Levodopa + Carbidopa + Entacapone may include:

• Nausea
• Diarrhea
• Dizziness
• Sleepiness
• Orange-brown urine discoloration
• Involuntary movements (dyskinesia), which may be more noticeable as the dose is increased

• Syncapone 50 Tablet can cause dizziness or sleepiness, so use caution with driving, biking, or machinery until you know how it affects you.
• Avoid alcohol, which can worsen drowsiness and lightheadedness.
• Tell your doctor if you have a history of heart disease, low blood pressure, liver disease, kidney problems, or mental health conditions.
• Do not use with or soon after nonselective MAO inhibitors; dangerous interactions can occur.
• This tablet can increase involuntary movements and confusion, especially if the dose is too high for you.
• Tell your prescriber about all medicines for depression, blood pressure, nausea, sleep, or Parkinson’s disease before starting Syncapone 50 Tablet.
• Stand up slowly from sitting or lying positions to reduce the risk of falls from low blood pressure.

• Nonselective MAO inhibitors such as phenelzine or tranylcypromine
• Antipsychotic medicines and some anti-nausea drugs that block dopamine
• Iron supplements, which can reduce levodopa absorption
• Blood pressure medicines, which may increase dizziness or fainting
• Other Parkinson’s medicines containing levodopa or COMT inhibitors

Store Syncapone 50 Tablet at room temperature in its original strip/box, away from moisture, heat, and direct light.