Seretide 250 mcg Accuhaler

Seretide 250 mcg Accuhaler is a prescription inhaled medicine used to help control asthma symptoms. Each dose contains salmeterol 250 mcg and fluticasone propionate in an Accuhaler dry-powder inhaler dose. It combines a long-acting bronchodilator with an inhaled corticosteroid to help prevent wheeze, cough, chest tightness, and shortness of breath. Seretide 250 mcg Accuhaler is for maintenance treatment, not for quick relief of sudden asthma attacks.

How it works: Salmeterol relaxes the muscles around the airways so they stay open longer and breathing feels easier. Fluticasone propionate reduces airway inflammation and swelling in the lungs, which helps prevent asthma symptoms when this Accuhaler is used regularly.

Seretide 250 mcg Accuhaler is a higher-strength option than Seretide 50 mcg/250 mcg Accuhaler and a lower-strength option than Seretide 50 mcg/500 mcg Accuhaler. A doctor may choose this strength when a lower dose is not enough to keep asthma under control, but the higher steroid exposure is still appropriate for the patient. It is meant for people who have been assessed and need this specific maintenance strength, not for first-time self-starting.

• Maintenance treatment of asthma
• Prevention of wheezing and chest tightness
• Long-term control of shortness of breath
• Reducing asthma flare-ups when used as prescribed
• Improving day-to-day breathing in people who need combination therapy

• Use Seretide 250 mcg Accuhaler exactly as your doctor prescribed; do not take extra doses for sudden symptoms.
• This is a dry-powder inhaler dose, so inhale the medicine into the lungs rather than swallowing it like a tablet.
• Open the Accuhaler only when you are ready to take a dose, and keep the device dry.
• Breathe out fully away from the mouthpiece before inhaling the dose.
• After inhaling, hold your breath for a few seconds if you can, then breathe out slowly.
• Rinse your mouth with water and spit it out after use to help lower the risk of thrush.
• If you miss a dose, take it when remembered unless it is almost time for the next dose; do not double up.

Each dose of Seretide 250 mcg Accuhaler provides salmeterol 250 mcg with fluticasone propionate in one inhalation. The exact dosing schedule is set by the prescriber, commonly twice daily for maintenance asthma control, and the total daily amount should not exceed the amount your doctor has directed. Because this is a higher-strength maintenance product, it should be used only under medical supervision and not adjusted on your own.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Salmeterol + Fluticasone Propionate may include:

• Hoarseness or voice changes
• Throat irritation
• Oral thrush (more likely if the mouth is not rinsed after use)
• Headache
• Tremor or shakiness
• Fast heartbeat or palpitations
• Cough after inhalation

• Seretide 250 mcg Accuhaler is not a rescue inhaler and will not treat a sudden asthma attack.
• Because this is a higher-strength combination, use it only if your clinician has decided this dose is appropriate for your asthma severity.
• Tell your doctor if you have heart disease, high blood pressure, thyroid disease, diabetes, seizures, or low potassium.
• Use extra caution if you are taking medicines that can affect the heart rhythm or raise the risk of side effects.
• Rinse and spit after each dose to reduce mouth infections from the inhaled steroid.
• Tell your clinician if you have ever had tuberculosis, fungal infections, or recurrent chest infections.
• Do not stop this medicine suddenly unless your prescriber tells you to do so.

• Strong CYP3A4 inhibitors such as ritonavir or ketoconazole can increase fluticasone exposure and side effects.
• Other long-acting beta agonists should not be used together with Seretide 250 mcg Accuhaler unless specifically directed.
• Beta-blockers may reduce the bronchodilator effect and can worsen asthma in some patients.
• Diuretics or other medicines that lower potassium may increase the risk of low potassium levels.
• Some antidepressants and other drugs that affect heart rhythm may increase the chance of palpitations or rhythm problems.

Store Seretide 250 mcg Accuhaler in a dry place at room temperature, keep it closed when not in use, and protect it from moisture.