Seroflo Rotacaps 50 mcg + 250 mcg

Seroflo Rotacaps 50 mcg + 250 mcg is a prescription inhalation medicine used to help control asthma symptoms. Each rotacap contains salmeterol 50 mcg and fluticasone propionate 250 mcg, a long-acting beta2-agonist plus an inhaled corticosteroid. It is used as a maintenance treatment to reduce wheezing, shortness of breath, chest tightness, and flare-ups. Seroflo Rotacaps 50 mcg + 250 mcg is not a rescue medicine for sudden asthma attacks.

How it works: Salmeterol relaxes the muscles around the airways so air can move in and out more easily, while fluticasone reduces swelling and irritation inside the lungs. In this rotacap form, the powder is inhaled through a compatible dry-powder device so the medicine goes directly to the airways.

Seroflo Rotacaps 50 mcg + 250 mcg is a mid-to-higher maintenance strength, so it is usually chosen when a doctor wants more anti-inflammatory control than the 50 mcg + 100 mcg capsule provides. It may be appropriate for people whose asthma is not well controlled on a lower strength, but who do not yet need the higher 50 mcg + 500 mcg strength. The 50 mcg rotacap refers to the salmeterol amount in each capsule, while the fluticasone dose is 250 mcg.

• Maintenance treatment of asthma
• Prevention of day-to-day wheezing and chest tightness
• Reduction of asthma flare-ups
• Long-term control of airway inflammation
• Improving breathing in people needing combination therapy

• Use Seroflo Rotacaps 50 mcg + 250 mcg only with the inhaler device intended for rotacaps; do not swallow the capsule.
• Open the capsule only when you are ready to inhale the dose, and use each rotacap once.
• Inhale the full contents as directed by your doctor; do not chew, break, or mix the powder with food or water.
• Take it at the same times each day for regular control, even if you feel well.
• It is not meant for sudden asthma attacks; keep a fast-acting rescue inhaler for emergencies.
• Rinse your mouth with water after use and spit it out to lower the risk of oral thrush.

Each Seroflo Rotacaps 50 mcg + 250 mcg capsule delivers salmeterol 50 mcg and fluticasone propionate 250 mcg per inhalation. The usual frequency is often twice daily for maintenance, but the exact schedule and the maximum daily use must be set by the prescriber based on asthma severity and response. Do not increase the number of rotacaps on your own, because this is a prescription maintenance strength and not a rescue medicine.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Salmeterol + Fluticasone Propionate may include:

• Throat irritation
• Hoarseness
• Cough after inhalation
• Oral thrush (more likely if you do not rinse your mouth)
• Headache
• Tremor or shakiness
• Fast heartbeat or palpitations

• Do not use Seroflo Rotacaps 50 mcg + 250 mcg for sudden asthma attacks.
• This higher maintenance strength should be used only if a clinician has decided the 250 mcg fluticasone dose is appropriate for you.
• Rinse and spit after each use to help prevent mouth yeast infection.
• Use caution if you have heart disease, high blood pressure, arrhythmia, thyroid disease, diabetes, or seizures.
• Tell your doctor if you have ever had tuberculosis, fungal infections, or recurrent pneumonia.
• Some people may feel shaky or have a faster heartbeat after inhaling it, which can affect driving until they know how it affects them.
• Avoid changing other asthma medicines abruptly unless your prescriber instructs you to do so.

• Other LABA medicines, because combining them can increase side effects
• Strong CYP3A4 inhibitors such as ritonavir, cobicistat, ketoconazole, or clarithromycin
• Beta-blockers such as propranolol or timolol, which can reduce bronchodilation
• Diuretics and some steroids, which may raise the risk of low potassium
• Other corticosteroids, which can increase steroid-related side effects

Store Seroflo Rotacaps 50 mcg + 250 mcg in the original strip/box at room temperature, away from moisture and heat, and keep the capsules in the blister until use.