Sitaxa M XR 100+500 Tablet

Sitaxa M XR 100+500 Tablet is a prescription diabetes medicine that combines sitagliptin 100 mg and metformin 500 mg in each tablet. It belongs to the DPP-4 inhibitor plus biguanide class and is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes. This tablet is not for type 1 diabetes or diabetic ketoacidosis.

How it works: Sitagliptin helps the body release more insulin after meals and lowers the amount of sugar made by the liver indirectly by improving hormone signals. Metformin reduces sugar production in the liver and helps the body use insulin better, so this tablet works from two different angles to lower blood glucose.

Sitaxa M XR 100+500 Tablet is a higher-strength combination tablet, pairing a full sitagliptin 100 mg dose with metformin 500 mg in one tablet. Doctors may choose this strength for people who need stronger glucose-lowering support than lower-dose options can provide, or who are already established on these medicines and need an easier once-daily tablet regimen.

• Type 2 diabetes blood sugar control
• Use with diet and exercise
• Combination therapy when one medicine is not enough
• Adjunct treatment to improve HbA1c

• Swallow Sitaxa M XR 100+500 Tablet whole with water; do not crush, chew, or split it.
• Take it exactly as prescribed, usually once daily, because this strength is an extended-release combination tablet.
• Take it with food if your prescriber or pharmacist advises, especially to reduce stomach upset from metformin.
• Take it at the same time each day to help keep blood sugar levels steady.
• If you miss a dose, take it when you remember unless it is almost time for the next dose; do not double up.
• Do not change how you take this tablet without checking with your doctor, especially if you have kidney problems.

Each Sitaxa M XR 100+500 Tablet provides sitagliptin 100 mg and metformin 500 mg. The dose is typically taken once daily, but your doctor may adjust your regimen based on blood sugar control, kidney function, and how well you tolerate it. Do not exceed the daily amount prescribed by your clinician; this strength should only be used under medical supervision.

Do not change your dose or stop the medicine without speaking to your doctor.

Common side effects of Sitagliptin + Metformin may include:

• Nausea, especially when starting treatment
• Diarrhea
• Stomach upset or abdominal pain
• Gas or bloating
• Headache
• Runny nose or upper respiratory symptoms
• Low blood sugar can happen if combined with other diabetes medicines

• This is a stronger combination tablet, so it should be used only if your doctor has assessed that 100 mg sitagliptin plus 500 mg metformin is appropriate.
• Do not use it for type 1 diabetes or diabetic ketoacidosis.
• Tell your doctor if you have kidney disease, because metformin-containing tablets may not be suitable or may need close monitoring.
• Avoid heavy alcohol use, which can raise the risk of serious metformin-related side effects.
• Use caution when driving or operating machinery until you know how this medicine affects your blood sugar.
• If you take insulin or a sulfonylurea, the risk of low blood sugar is higher.
• Tell your clinician about heart failure, liver disease, or a history of pancreatitis before starting this tablet.

• Alcohol can increase the risk of lactic acidosis with metformin.
• Insulin and sulfonylureas can increase the risk of hypoglycemia.
• Iodinated contrast dye used for some imaging tests may require the medicine to be held temporarily.
• Certain kidney-affecting drugs, including some diuretics or NSAIDs, may raise metformin risk in some patients.
• Other diabetes medicines may need dose changes to avoid low blood sugar.

Store Sitaxa M XR 100+500 Tablet in its original strip/box at room temperature, away from moisture and excess heat, and keep it out of reach of children.